The Chinese Herbal Medicine Formula mKG Suppresses Pulmonary Fibrosis of Mice Induced by Bleomycin

Pulmonary fibrosis (PF) is a serious progressive lung disease and it originates from inflammation-induced parenchymal injury with excessive extracellular matrix deposition to result in the destruction of the normal lung architecture. Modified Kushen Gancao Formula (mKG), derived from traditional Chi...

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Bibliographic Details
Published in:International journal of molecular sciences 2016-02, Vol.17 (2), p.238-238
Main Authors: Gao, Ying, Yao, Li-Fu, Zhao, Yang, Wei, Li-Man, Guo, Peng, Yu, Meng, Cao, Bo, Li, Tan, Chen, Hong, Zou, Zhong-Mei
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
Antibiotics, Antineoplastic - adverse effects
bleomycin
Bleomycin - adverse effects
Clinical outcomes
Cytokines - genetics
Cytokines - metabolism
Disease Models, Animal
Drugs, Chinese Herbal - pharmacology
Gene Expression
Herbal medicine
Immunohistochemistry
Inflammation
Inflammation Mediators
Male
Mice
mKG (Modified Kushen Gancao Formula)
Pulmonary fibrosis
Pulmonary Fibrosis - chemically induced
Pulmonary Fibrosis - drug therapy
Pulmonary Fibrosis - genetics
Pulmonary Fibrosis - metabolism
Pulmonary Fibrosis - pathology
RNA, Messenger - genetics
RNA, Messenger - metabolism
Rodents
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Summary:Pulmonary fibrosis (PF) is a serious progressive lung disease and it originates from inflammation-induced parenchymal injury with excessive extracellular matrix deposition to result in the destruction of the normal lung architecture. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicine, has a prominent anti-inflammatory effect. The present study is to explore the inhibitory effects of mKG on bleomycin (BLM)-induced pulmonary fibrosis in mice. mKG significantly decreased pulmonary alveolitis, fibrosis scores, and interleukin-6 (IL-6), interleukin-17 (IL-17), transforming growth factor-β (TGF-β) and hydroxyproline (HYP) levels in lung tissue of mice compared with BLM treatment. It markedly alleviated the increase of HYP content in the lung tissues and pathologic changes of pulmonary fibrosis caused by BLM instillation. In conclusion, mKG has an anti-fibrotic effect and might be employed as a therapeutic candidate agent for attenuating pulmonary fibrosis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms17020238