Postpartum multiple vertebral fractures in a patient with osteogenesis imperfecta type I: A case report and literature review

A 39-year-old woman with type I osteogenesis imperfecta reported experiencing back pain at 35 weeks of gestation. Two days following an elective cesarean section, the patient developed a Th12 vertebral compression fracture; 3 weeks postoperatively, she sustained an L3 vertebral compression fracture....

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Bibliographic Details
Published in:Case reports in women's health 2024-12, Vol.44, p.e00666, Article e00666
Main Authors: Miyazaki, Yumiko, Hosokawa, Mizuki, Kudo, Sho, Onuma, Toshimichi, Orisaka, Makoto, Yoshida, Yoshio
Format: Article
Language:English
Subjects:
Bone mineral density
Fracture
Osteogenesis imperfecta
Osteoporosis
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Summary:A 39-year-old woman with type I osteogenesis imperfecta reported experiencing back pain at 35 weeks of gestation. Two days following an elective cesarean section, the patient developed a Th12 vertebral compression fracture; 3 weeks postoperatively, she sustained an L3 vertebral compression fracture. The patient displayed a lumbar spine Z-score of −1.7; she subsequently discontinued breastfeeding, and treatment with active vitamin D was initiated. Genetic testing confirmed a diagnosis of osteogenesis imperfecta. •Osteogenesis imperfecta increases the risk of pregnancy- and lactation-associated osteoporosis but there are few reports of such cases in the literature.•Little is known about the risk factors for fractures and their management during pregnancy or the postpartum period.•We report the case of a patient with type I osteogenesis imperfecta who developed multiple spinal fractures during the postpartum period.•The patient chose to discontinue breastfeeding, and started on vitamin D supplementation.
ISSN:2214-9112
2214-9112
DOI:10.1016/j.crwh.2024.e00666