Adjusting the Molecular Clock: The Importance of Circadian Rhythms in the Development of Glioblastomas and Its Intervention as a Therapeutic Strategy

Gliomas are solid tumors of the central nervous system (CNS) that originated from different glial cells. The World Health Organization (WHO) classifies these tumors into four groups (I–IV) with increasing malignancy. Glioblastoma (GBM) is the most common and aggressive type of brain tumor classified...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-08, Vol.22 (15), p.8289
Main Authors: Wagner, Paula M., Prucca, César G., Caputto, Beatriz L., Guido, Mario E.
Format: Article
Language:English
Subjects:
Biological clocks
Biopsy
Brain cancer
Brain tumors
Cell cycle
Cell growth
Central nervous system
Circadian rhythm
Circadian rhythms
Dehydrogenases
DNA methylation
Enzymes
Gene expression
Glial cells
Glioblastoma
Growth factors
Kinases
Malignancy
Medical prognosis
Morphology
Mutation
Proteins
Review
Solid tumors
Stem cells
treatment
Tumor cells
Tumors
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Summary:Gliomas are solid tumors of the central nervous system (CNS) that originated from different glial cells. The World Health Organization (WHO) classifies these tumors into four groups (I–IV) with increasing malignancy. Glioblastoma (GBM) is the most common and aggressive type of brain tumor classified as grade IV. GBMs are resistant to conventional therapies with poor prognosis after diagnosis even when the Stupp protocol that combines surgery and radiochemotherapy is applied. Nowadays, few novel therapeutic strategies have been used to improve GBM treatment, looking for higher efficiency and lower side effects, but with relatively modest results. The circadian timing system temporally organizes the physiology and behavior of most organisms and daily regulates several cellular processes in organs, tissues, and even in individual cells, including tumor cells. The potentiality of the function of the circadian clock on cancer cells modulation as a new target for novel treatments with a chronobiological basis offers a different challenge that needs to be considered in further detail. The present review will discuss state of the art regarding GBM biology, the role of the circadian clock in tumor progression, and new chrono-chemotherapeutic strategies applied for GBM treatment.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22158289