The Roles of Noncoding RNAs in Systemic Sclerosis

Noncoding RNAs (ncRNAs) constitute more than 90% of the RNAs in the human genome. In the past decades, studies have changed our perception of ncRNAs from "junk" transcriptional products to functional regulatory molecules that mediate critical processes, including chromosomal modifications,...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2022-04, Vol.13, p.856036-856036
Main Authors: Liu, Yongmei, Cheng, Linlin, Zhan, Haoting, Li, Haolong, Li, Xiaomeng, Huang, Yuan, Li, Yongzhe
Format: Article
Language:English
Subjects:
biomarker
Biomarkers - metabolism
function
Humans
Immunology
lncRNA
MicroRNAs - genetics
miRNA
ncRNA
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA, Untranslated - genetics
RNA, Untranslated - metabolism
Scleroderma, Systemic - genetics
Scleroderma, Systemic - therapy
systemic sclerosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Noncoding RNAs (ncRNAs) constitute more than 90% of the RNAs in the human genome. In the past decades, studies have changed our perception of ncRNAs from "junk" transcriptional products to functional regulatory molecules that mediate critical processes, including chromosomal modifications, mRNA splicing and stability, and translation, as well as key signaling pathways. Emerging evidence suggests that ncRNAs are abnormally expressed in not only cancer but also autoimmune diseases, such as systemic sclerosis (SSc), and may serve as novel biomarkers and therapeutic targets for the diagnosis and treatment of SSc. However, the functions and underlying mechanisms of ncRNAs in SSc remain incompletely understood. In this review, we discuss the current findings on the biogenetic processes and functions of ncRNAs, including microRNAs and long noncoding RNAs, as well as explore emerging ncRNA-based diagnostics and therapies for SSc.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.856036