Associations of anaemia with bleeding and thrombotic complications in patients with atrial fibrillation treated with warfarin: a registry-based nested case–control study

ObjectivesWe studied association of laboratory testing beyond the international normalised ratio (INR) with bleeding and stroke/transient ischaemic attack (TIA) outcomes in patients with atrial fibrillation treated with warfarin.DesignThis was a retrospective nested case–control study from the Finni...

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Bibliographic Details
Published in:BMJ open 2023-11, Vol.13 (11), p.e071342-e071342
Main Authors: Helin, Tuukka Antero, Raatikainen, Pekka, Lehto, Mika, Haukka, Jari, Lassila, Riitta
Format: Article
Language:English
Subjects:
Anemia
Anticoagulants
Bleeding disorders & coagulopathies
Blood tests
Cardiac arrhythmia
Cardiovascular Medicine
Creatinine
Hemoglobin
Ischemia
Laboratories
Leukocytes
Mortality
Patients
Stroke
Thromboembolism
Transient ischemic attack
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Summary:ObjectivesWe studied association of laboratory testing beyond the international normalised ratio (INR) with bleeding and stroke/transient ischaemic attack (TIA) outcomes in patients with atrial fibrillation treated with warfarin.DesignThis was a retrospective nested case–control study from the Finnish Warfarin in Atrial Fibrillation (FinWAF) registry (n=54 568), reporting the management and outcome in warfarin-anticoagulated patients. Associations of blood count test frequency and results were assessed together with risk of bleeding or stroke/TIA during 5-year follow-up.SettingNational FinWAF registry, with data from all six hospital districts. Follow-up period for complications was 1 January 2007–31 December 2011.ParticipantsA total of 54 568 warfarin-anticoagulated patients.ResultsThe number of patients with bleeding was 4681 (9%) and stroke/TIA episodes, 4692 (9%). In patients with bleeds, lower haemoglobin (within 3 months) preceded the event compared with the controls (median 126 vs 135 g/L; IQR 111–141 g/L vs 123–147 g/L, p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2022-071342