Postoperative acute kidney injury after on-pump cardiac surgery in patients with connective tissue disease

• Published in: Frontiers in cardiovascular medicine 2023-11, Vol.10, p.1266549-1266549
• Main Authors: Zhang, Xue, Miao, Qi, Yu, Chunhua, Zhang, Yuelun, Wu, Di, Tian, Yajie, Li, Hanchen, Wang, Chunrong
• Format: Article
• Language: English
• Subjects: acute kidney injury; body mass index; cardiac surgery; connective tissue disease; systemic lupus erythematosus
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2023.1266549

ObjectivePatients with connective tissue disease have a poor prognosis after receiving cardiac surgery. This study described the clinical scenarios and investigated factors correlated with acute kidney injury (AKI) after on-pump cardiac surgery in patients with systemic lupus erythematosus (SLE) or vasculitis.MethodsPatients with SLE or vasculitis who underwent on-pump cardiac surgery from March 2002 to March 2022 were enrolled, while patients with preoperative renal dysfunction were excluded. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Uni- and multivariable analyses were performed to identify potential factors associated with postoperative AKI.ResultsAmong 123 patients enrolled, 39 (31.7%) developed AKI within seven days after receiving on-pump cardiac surgery. Four patients died in the hospital, resulting in an overall in-hospital mortality of 3.3%, and all deaths occurred in the AKI group. Patients in the AKI group also had longer ICU stays (median difference 3.0 day, 95% CI: 1.0-4.0, P