Empty follicle syndrome: Successful pregnancy following dual trigger

Empty follicle syndrome (EFS) is an uncommon, but the frustrating complication of assisted reproductive technology with failure to obtain oocytes after an adequate ovarian response to stimulation. Most of the reported cases of EFS are drug-related problems which are actually avoidable and do not rep...

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Bibliographic Details
Published in:Journal of human reproductive sciences 2015-07, Vol.8 (3), p.170-174
Main Authors: Deepika, K, Rathore, Suvarna, Garg, Nupur, Rao, Kamini
Format: Article
Language:English
Subjects:
Care and treatment
Case Report
Case studies
Conflicts of interest
Dual trigger
empty follicle syndrome
genuine empty follicle syndrome
gonadotropin-releasing hormone antagonist
Human fertilization in vitro
Infertility
Menstruation
Methods
Ovarian diseases
Patient outcomes
Patients
Pregnancy
Ultrasonic imaging
Women
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Description
Summary:Empty follicle syndrome (EFS) is an uncommon, but the frustrating complication of assisted reproductive technology with failure to obtain oocytes after an adequate ovarian response to stimulation. Most of the reported cases of EFS are drug-related problems which are actually avoidable and do not represent any potential pathology and that the risk of genuine EFS (GEFS) is much smaller than was once thought. Our case is thefirst report of a pregnancy obtained after management of GEFS with dual trigger in a gonadotropin-releasing hormone (GnRH) antagonist cycle. In this report, we present a patient who underwent two oocyte retrievals, in which no oocytes were obtained. In the third in-vitrofertilization cycle, a dual trigger with the combination of GnRH agonist and human chorionic gonadotropin yielded 11 oocytes, which led to the transfer of 2 blastocysts resulting in a live birth. Changing the treatment protocol with dual trigger brought about a successful outcome.
ISSN:0974-1208
1998-4766
DOI:10.4103/0974-1208.165152