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Empty follicle syndrome: Successful pregnancy following dual trigger

Empty follicle syndrome (EFS) is an uncommon, but the frustrating complication of assisted reproductive technology with failure to obtain oocytes after an adequate ovarian response to stimulation. Most of the reported cases of EFS are drug-related problems which are actually avoidable and do not rep...

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Published in:	Journal of human reproductive sciences 2015-07, Vol.8 (3), p.170-174
Main Authors:	Deepika, K, Rathore, Suvarna, Garg, Nupur, Rao, Kamini
Format:	Article
Language:	English
Subjects:	Care and treatment Case Report Case studies Conflicts of interest Dual trigger empty follicle syndrome genuine empty follicle syndrome gonadotropin-releasing hormone antagonist Human fertilization in vitro Infertility Menstruation Methods Ovarian diseases Patient outcomes Patients Pregnancy Ultrasonic imaging Women
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container_title	Journal of human reproductive sciences
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creator	Deepika, K Rathore, Suvarna Garg, Nupur Rao, Kamini
description	Empty follicle syndrome (EFS) is an uncommon, but the frustrating complication of assisted reproductive technology with failure to obtain oocytes after an adequate ovarian response to stimulation. Most of the reported cases of EFS are drug-related problems which are actually avoidable and do not represent any potential pathology and that the risk of genuine EFS (GEFS) is much smaller than was once thought. Our case is thefirst report of a pregnancy obtained after management of GEFS with dual trigger in a gonadotropin-releasing hormone (GnRH) antagonist cycle. In this report, we present a patient who underwent two oocyte retrievals, in which no oocytes were obtained. In the third in-vitrofertilization cycle, a dual trigger with the combination of GnRH agonist and human chorionic gonadotropin yielded 11 oocytes, which led to the transfer of 2 blastocysts resulting in a live birth. Changing the treatment protocol with dual trigger brought about a successful outcome.
doi_str_mv	10.4103/0974-1208.165152
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source	Publicly Available Content (ProQuest); IngentaConnect Journals; PubMed Central
subjects	Care and treatment Case Report Case studies Conflicts of interest Dual trigger empty follicle syndrome genuine empty follicle syndrome gonadotropin-releasing hormone antagonist Human fertilization in vitro Infertility Menstruation Methods Ovarian diseases Patient outcomes Patients Pregnancy Ultrasonic imaging Women
title	Empty follicle syndrome: Successful pregnancy following dual trigger
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