Effect of yerba mate and green tea on paraoxonase and leptin levels in patients affected by overweight or obesity and dyslipidemia: a randomized clinical trial

• Published in: Nutrition journal 2019-01, Vol.18 (1), p.5-5, Article 5
• Main Authors: Balsan, Guilherme, Pellanda, Lúcia Campos, Sausen, Grasiele, Galarraga, Thaís, Zaffari, Denise, Pontin, Bruna, Portal, Vera Lúcia
• Format: Article
• Language: English
• Subjects: Adult; antioxidant activity; Antioxidants; Antioxidants - analysis; apples; Arteriosclerosis; aryldialkylphosphatase; Aryldialkylphosphatase - blood; Atherosclerosis; Beverages; blood serum; Body Mass Index; Body weight; Cardiovascular disease; Cholesterol, HDL - blood; Clinical trials; Coronary artery; coronary artery disease; Diabetes; Dyslipidemia; Dyslipidemias - blood; Enzyme-linked immunosorbent assay; Enzymes; Female; Gene expression; Green tea; Heart diseases; High density lipoprotein; Homeostasis; Humans; hyperlipidemia; Ilex paraguariensis - chemistry; Insulin; Leptin; Leptin - blood; Lipoproteins; Male; men; Metabolic disorders; Metabolism; Middle Aged; Nutrition research; Obesity; Obesity - blood; Overweight; Overweight - blood; Paraoxonase; Paraoxonase-1 (PON-1); patients; Peptides; Phytotherapy; Plant Extracts - administration & dosage; protective effect; protocols; randomized clinical trials; Rodents; Serum levels; Tea; Weight control; women; Yerba mate
• ISSN: 1475-2891; 1475-2891
• DOI: 10.1186/s12937-018-0426-y

This study aimed to evaluate the effect of the intake of yerba mate (YM) and green tea (GT) on serum levels of leptin and paraoxonase-1 (PON-1), compared to control. Controlled, randomized clinical trial (RCT) that evaluated 142 men and women affected by overweight or obesity aged 35-60 years, untreated dyslipidemia and no history of coronary artery disease. Participants were randomized to ingest 1000 mL GT, YM or apple tea (AT, control group) daily, during eight weeks. Serum PON-1 and leptin levels were analyzed by ELISA immunoassay at the beginning (baseline) and after eight weeks of intervention. The intake of 1 l of YM/day resulted in significant increase in serum levels of PON-1 (9.7%; p = 0.005). The consumption of GT induced no significant difference in the levels of PON-1 (p = 0.154) and leptin (p = 0.783). Intergroup analysis showed a significant difference (p = 0.036) in the variation of PON-1 levels in the YM group when compared to GT and AT groups. In addition, the increase in PON-1 levels in the YM group was significantly associated with increased HDL-c (p = 0.004). The intake of yerba mate increased the antioxidant capacity by increasing serum levels of PON-1 and was positively associated with increased HDL-c, stressing the protective role of this beverage against atherosclerotic diseases. GT intake had no significant effect on serum levels of PON-1 and leptin. This study is registered with ClinicalTrials.gov under protocol number NCT00933647.