Prevalence, genotypes and risk factors associated with hepatitis C virus infection in hemodialysis patients in Campo Grande, MS, Brazil

• Published in: Memórias do Instituto Oswaldo Cruz 2008-06, Vol.103 (4), p.405-408
• Main Authors: Freitas, Solange Z, da Cunha, Rivaldo V, Martins, Regina MB, Teles, Sheila A, Ibanhes, Mary L, Motta-Castro, Ana RC
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Brazil - epidemiology; Enzyme-Linked Immunosorbent Assay; Female; Genotype; genotypes; hemodialysis; Hepacivirus - immunology; Hepatitis C - diagnosis; Hepatitis C - epidemiology; Hepatitis C - transmission; Hepatitis C Antibodies - blood; Hepatitis C virus; hepatitis C virus - hemodialysis - prevalence - genotypes - risk factors; Humans; Male; Middle Aged; PARASITOLOGY; Prevalence; Renal Dialysis - adverse effects; Risk Factors; RNA, Viral - genetics; TROPICAL MEDICINE
• ISSN: 1678-8060; 0074-0276; 1678-8060; 0074-0276
• DOI: 10.1590/S0074-02762008000400016

A survey was conducted among the hemodialysis units of the city of Campo Grande, located in the state of Mato Grosso do Sul in the Mid-west region of Brazil, with the aim of investigating the prevalence, risk factors, and genotypes of hepatitis C virus (HCV) infection. A total of 163 patients were interviewed in five dialysis units. Serum samples were screened for anti-HCV. Positive samples were tested for HCV RNA and genotyped. The prevalence of anti-HCV was 11% (95% CI: 6.8-17.1). A history of transfusion with blood that was not screened for anti-HCV and length of time on hemodialysis were associated with HCV infection. HCV RNA was detected in 12 samples: ten were of genotype 1, subtypes 1a (75%) and 1b (8.3%), and two were of genotype 3, subtype 3a (16.7%).