Antiphospholipid syndrome with chronic thromboembolic pulmonary hypertension and coronary artery disease: a case report

• Published in: Journal of cardiothoracic surgery 2020-08, Vol.15 (1), p.225-225, Article 225
• Main Authors: Sugiyama, Kayo, Suzuki, Shun, Koizumi, Nobusato, Ogino, Hitoshi
• Format: Article
• Language: English
• Subjects: Adult; Angiography; Angioplasty; Antibodies; Anticoagulants; Antiphospholipid antibodies; Antiphospholipid syndrome; Antiphospholipid Syndrome - complications; Antiphospholipid Syndrome - diagnosis; Antiphospholipid Syndrome - physiopathology; Antiplatelet therapy; Asymptomatic; Autoimmune diseases; Bleeding; Bypass; Cardiovascular disease; Care and treatment; Case Report; Case reports; Chronic thromboembolic pulmonary hypertension; Coronary Angiography - adverse effects; Coronary artery; Coronary artery bypass; Coronary Artery Bypass - adverse effects; Coronary artery bypass grafting; Coronary artery disease; Coronary Artery Disease - complications; Coronary Artery Disease - surgery; Coronary heart disease; Coronary vessels; Diagnostic imaging; Echocardiography; Endarterectomy; Eplerenone; Female; Grafting; Heart; Heart attacks; Heart diseases; Heart surgery; Humans; Hypertension; Hypertension, Pulmonary - complications; Hypertension, Pulmonary - surgery; Hypothermia; Hypoxia; Laboratories; Medical imaging; Oxygen therapy; Pain; Patients; Perioperative Period; Pulmonary arteries; Pulmonary artery; Pulmonary Artery - surgery; Pulmonary Embolism - complications; Pulmonary Embolism - surgery; Pulmonary endarterectomy; Pulmonary hypertension; Riociguat; Scintigraphy; Stenosis; Thrombocytopenia; Thromboembolism; Thrombosis; Treatment Outcome; Ventricle
• ISSN: 1749-8090; 1749-8090
• DOI: 10.1186/s13019-020-01254-4

Antiphospholipid syndrome (APS) is characterized by the production of antiphospholipid antibodies associated with recurrent vascular thrombosis. There have been few reports of combination of chronic thromboembolic pulmonary hypertension (CTEPH) and coronary artery disease in APS, therefore, it is unclear about appropriate treatment strategy. The patient was a 39 year-old-lady who had been suffering from hypoxia without chest pain. Transthoracic echocardiography showed severe pulmonary hypertension and mild hypokinesis of left ventricular anteroseptal wall. Simultaneously with the diagnosis of CTEPH, coronary angiography revealed severe stenosis of the left anterior descending artery. She underwent pulmonary endarterectomy (PEA) concomitant with coronary artery bypass grafting (CABG) successfully. CABG could be performed concomitantly during rewarming. During perioperative period, she was free from any thromboembolic and bleeding events despite receiving anticoagulant and antiplatelet therapies. PEA concomitant with coronary artery bypass grafting was feasible for APS patients complicated with CTEPH and coronary artery disease. APS patients with the presence of left ventricular dysfunction should be evaluated for coronary artery disease.