Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis

Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century...

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Bibliographic Details
Published in:Frontiers in neuroscience 2013-01, Vol.7, p.71-71
Main Authors: Choi, Yun-Hee, Fujikawa, Teppei, Lee, Jiwon, Reuter, Anne, Kim, Ki Woo
Format: Article
Language:English
Subjects:
Arcuate nucleus of the hypothalamus
Brain research
Brain-derived neurotrophic factor
Cloning
Diabetes
Diabetes mellitus
Endocrinology
Energy
Energy balance
Energy expenditure
energy homeostasis
Food intake
Gene expression
Genetic engineering
Glucose
Glucose homeostasis
Homeostasis
Hypothalamus (medial)
Hypothalamus (ventromedial)
Insulin resistance
knockout
Metabolism
Nervous system
Neurons
Neuroscience
Obesity
Physiology
Public health
Steroidogenic Factor 1
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Summary:Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century, the ventral medial nucleus of the hypothalamus (VMH) was the first site reported to play a prominent role in the regulation of energy homeostasis through control of food intake and energy expenditure. Recent studies using sophisticated genetic tools have further highlighted the importance of the VMH and have extended our understanding of the physiological role of the nucleus in regulation of energy homeostasis. These genetic studies were preceded by the identification of steroidogenic factor-1 (SF-1) as a marker of the VMH. This review focuses on the emerging homeostatic roles of the SF-1 neurons in the VMH discovered through the use of genetic models, particularly highlighting the control of energy, and glucose homeostasis.
ISSN:1662-4548
1662-4548
1662-453X
DOI:10.3389/fnins.2013.00071