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Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis

Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century...

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Published in:	Frontiers in neuroscience 2013-01, Vol.7, p.71-71
Main Authors:	Choi, Yun-Hee, Fujikawa, Teppei, Lee, Jiwon, Reuter, Anne, Kim, Ki Woo
Format:	Article
Language:	English
Subjects:	Arcuate nucleus of the hypothalamus Brain research Brain-derived neurotrophic factor Cloning Diabetes Diabetes mellitus Endocrinology Energy Energy balance Energy expenditure energy homeostasis Food intake Gene expression Genetic engineering Glucose Glucose homeostasis Homeostasis Hypothalamus (medial) Hypothalamus (ventromedial) Insulin resistance knockout Metabolism Nervous system Neurons Neuroscience Obesity Physiology Public health Steroidogenic Factor 1
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creator	Choi, Yun-Hee Fujikawa, Teppei Lee, Jiwon Reuter, Anne Kim, Ki Woo
description	Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century, the ventral medial nucleus of the hypothalamus (VMH) was the first site reported to play a prominent role in the regulation of energy homeostasis through control of food intake and energy expenditure. Recent studies using sophisticated genetic tools have further highlighted the importance of the VMH and have extended our understanding of the physiological role of the nucleus in regulation of energy homeostasis. These genetic studies were preceded by the identification of steroidogenic factor-1 (SF-1) as a marker of the VMH. This review focuses on the emerging homeostatic roles of the SF-1 neurons in the VMH discovered through the use of genetic models, particularly highlighting the control of energy, and glucose homeostasis.
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subjects	Arcuate nucleus of the hypothalamus Brain research Brain-derived neurotrophic factor Cloning Diabetes Diabetes mellitus Endocrinology Energy Energy balance Energy expenditure energy homeostasis Food intake Gene expression Genetic engineering Glucose Glucose homeostasis Homeostasis Hypothalamus (medial) Hypothalamus (ventromedial) Insulin resistance knockout Metabolism Nervous system Neurons Neuroscience Obesity Physiology Public health Steroidogenic Factor 1
title	Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis
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