Acute promyelocytic leukemia after whole brain irradiation of primary brain lymphomainan HIV-infected patient

The occurrence of acute promyelocytic leukemia (APL) in HIV-infected patients has been reported in only five cases. Due to a very small number of reported HIV/APL patients who have been treated with different therapies with the variable outcome, the prognosis of APL in the setting of the HIV-infecti...

Full description

Saved in:
Bibliographic Details
Published in:European journal of medical research 2009-01, Vol.14 (25), p.42-42, Article 42
Main Authors: Boban, A, Radman, I., Zadro, R., Dubravcic, K., Maretic, T., Civljak, R., Lisic, M., Begovac, J.
Format: Article
Language:English
Subjects:
Acute myelocytic leukemia
acute promyelocytic leukemia
Analysis
Antiretroviral agents
Development and progression
Highly active antiretroviral therapy
HIV
HIV infections
HIV patients
Infection
Lymphomas
primary central nervous system lymphoma
Prognosis
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The occurrence of acute promyelocytic leukemia (APL) in HIV-infected patients has been reported in only five cases. Due to a very small number of reported HIV/APL patients who have been treated with different therapies with the variable outcome, the prognosis of APL in the setting of the HIV-infection is unclear. Here, we report a case of an HIV-patient who developed APL and upon treatment entered a complete remission. A 25-years old male patient was diagnosed with HIV-infection in 1996, but remained untreated. In 2004, the patient was diagnosed with primary central nervous system lymphoma. We treated the patient with antiretroviral therapy and whole-brain irradiation, resulting in complete remission of the lymphoma. In 2006, prompted by a sudden neutropenia, we carried out a set of diagnostic procedures, revealing APL. Induction therapy consisted of standard treatment with all-trans-retinoic-acid (ATRA) and idarubicin. Subsequent cytological and molecular analysis of bone marrow demonstrated complete hematological and molecular remission. Due to the poor general condition, consolidation treatment with ATRA was given in March and April 2007. The last follow-up 14 months later, showed sustained molecular APL remission. In conclusion, we demonstrated that a complete molecular APL remission in an HIV-patient was achieved by using reduced-intensity treatment. Keywords: HIV, acute promyelocytic leukemia, primary central nervous system lymphoma
ISSN:2047-783X
0949-2321
2047-783X
DOI:10.1186/2047-783X-14-1-42