Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changes

Interstitial cells of Cajal (ICC) were first described by Santiago Ramon y Cajal over 100 years ago. They are thought to play an important role in the regulation of gastrointestinal motility. There is increasing evidence that the decline in their number in the gallbladder wall contributes to the for...

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Bibliographic Details
Published in:Polish journal of pathology 2019-01, Vol.70 (3), p.205-209
Main Authors: Spętana, Joanna, Lipiński, Artur, Jeleń, Michał
Format: Article
Language:English
Subjects:
Apoptosis
Cholecystitis - pathology
Cholelithiasis - pathology
distribution
Gallbladder
Gallbladder - cytology
Gallbladder - pathology
Gallbladder diseases
Humans
icc
Immunohistochemistry
Inflammation
interstitial cells of cajal
Interstitial Cells of Cajal - cytology
Medical research
Microscopy
Motility
Proto-Oncogene Proteins c-kit
Smooth muscle
Statistical analysis
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Summary:Interstitial cells of Cajal (ICC) were first described by Santiago Ramon y Cajal over 100 years ago. They are thought to play an important role in the regulation of gastrointestinal motility. There is increasing evidence that the decline in their number in the gallbladder wall contributes to the formation of concrements. The aim of the study was to determine the exact location of interstitial cells of Cajal in the gallbladder wall in patients with calculous and non-calculous cholecystitis. Sixty-eight patients were examined, of whom 50 were cases of cholelithiasis and 18 were of non-calculous cholecystitis. The technique of immunohistochemistry with the CD117 antibody was used to determine the cells of Cajal, while to distinguish them from mast cells the technique with mast cell tryptase (MCT) was applied. Redistribution of the interstitial cells of Cajal from the muscle membrane to lamina propria of mucous tissue was observed in the cases of cholelithiasis, while in the group of non-calculous cholecystitis most of the ICC was located within the muscle tissue.
ISSN:1233-9687
2084-9869
DOI:10.5114/pjp.2019.90397