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Development of an advanced synthetic route to macrosphelides and its application to the discovery of a more potent macrosphelide derivative

The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the success...

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Published in:	Molecules (Basel, Switzerland) Switzerland), 2014-09, Vol.19 (10), p.15572-15583
Main Authors:	Heo, Yu Mi, Lee, Hunseok, Shin, Young Kee, Paek, Seung-Mann
Format:	Article
Language:	English
Subjects:	Acids Alcohol Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Biological Products - chemistry Carbon Cell Line Cell Survival - drug effects Chemistry Chemistry Techniques, Synthetic Cytotoxicity Drug Discovery Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic Compounds - toxicity Humans macrosphelides Molecular Structure natural product Natural products Oxidation Pharmacy total synthesis
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description	The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the successful improvement of the cytotoxic activity of the macrosphelide derivative.
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subjects	Acids Alcohol Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Biological Products - chemistry Carbon Cell Line Cell Survival - drug effects Chemistry Chemistry Techniques, Synthetic Cytotoxicity Drug Discovery Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic Compounds - toxicity Humans macrosphelides Molecular Structure natural product Natural products Oxidation Pharmacy total synthesis
title	Development of an advanced synthetic route to macrosphelides and its application to the discovery of a more potent macrosphelide derivative
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