The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson’s disease

• Published in: Scientific reports 2024-06, Vol.14 (1), p.14670-15, Article 14670
• Main Authors: Gabbert, Carolin, Blöbaum, Leonie, Lüth, Theresa, König, Inke R., Caliebe, Amke, Sendel, Sebastian, Laabs, Björn-Hergen, Klein, Christine, Trinh, Joanne
• Format: Article
• Language: English
• Subjects: 631/208/727; 692/499; 692/699/375/1718; Age of Onset; Aged; Aspirin; Aspirin - therapeutic use; Caffeine; Case-Control Studies; Coffee; Female; GBA1; Gene-environment; Genetic Predisposition to Disease; Glucosylceramidase - genetics; Humanities and Social Sciences; Humans; Life Style; Lifestyles; Male; Middle Aged; Movement disorders; multidisciplinary; Multifactorial Inheritance; Neurodegenerative diseases; NSAID; Parkinson Disease - epidemiology; Parkinson Disease - genetics; Parkinson's disease; Proportional Hazards Models; Risk Factors; Science; Science (multidisciplinary); Smoking
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-65640-x

The objective of this study was to investigate the association between a Parkinson’s disease (PD)-specific polygenic score (PGS) and protective lifestyle factors on age at onset (AAO) in PD. We included data from 4367 patients with idiopathic PD, 159 patients with GBA1 -PD, and 3090 healthy controls of European ancestry from AMP-PD, PPMI, and Fox Insight cohorts. The association between PGS and lifestyle factors on AAO was assessed with linear and Cox proportional hazards models. The PGS showed a negative association with AAO ( β  = − 1.07, p  = 6 × 10 –7 ) in patients with idiopathic PD. The use of one, two, or three of the protective lifestyle factors showed a reduction in the hazard ratio by 21% ( p  = 0.0001), 44% ( p