The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor...

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Bibliographic Details
Published in:Frontiers in pharmacology 2023-08, Vol.14, p.1237723-1237723
Main Authors: Silva, Jéssica Manoelli Costa, Teixeira, Eliel Barbosa, Mourão, Ronald Matheus da Silva, Ferraz, Rafaella Sousa, Moreira, Fabiano Cordeiro, Assumpção, Paulo Pimentel de, Calcagno, Danielle Queiroz
Format: Article
Language:English
Subjects:
biomarkers
gastric cancer
gastric carcinogenesis
historical overview
long non-coding RNAs
molecular mechanisms
Pharmacology
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Summary:Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2023.1237723