Reference values for exhaled nitric oxide in healthy children aged 6-18 years in China: a cross-sectional, multicenter clinical study

The reference values of eNO have certain differences among people of different countries and races. We aimed to obtain the reference value of eNO in healthy children and adolescents (6-18 years old) in China and to explore the associations between the reference values with ages, gender, heights, BMI...

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Published in:Respiratory research 2024-09, Vol.25 (1), p.340-14, Article 340
Main Authors: Liu, Yazun, Zhang, Hao, Wang, Jinrong, Han, Yuling, Pan, Chunhong, Jiang, Wenhui, Ma, Chunyan, Shi, Yongsheng, Jia, Chunmei, Zhang, Yuehua, Li, Ming, Wang, Fei, Yu, Yanyan, Feng, Yong, Liu, Li, Liu, Aihong, Zhang, Qiaoling, Long, Zhen, Dai, Fuli, Zhang, Yanli, Ji, Minghong, Ma, Dongjun
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Analysis
Asthma
Biological markers
Body mass index
Breath Tests - methods
CaNO
Care and treatment
Child
Children and adolescents
China - epidemiology
Cross-Sectional Studies
Diagnosis
Dosage and administration
Exhalation - physiology
Female
FeNO200
FeNO50
Health aspects
Healthy Volunteers
Humans
Inflammation
Male
Nitric oxide
Nitric Oxide - analysis
Nitric Oxide - metabolism
Reference Values
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Summary:The reference values of eNO have certain differences among people of different countries and races. We aimed to obtain the reference value of eNO in healthy children and adolescents (6-18 years old) in China and to explore the associations between the reference values with ages, gender, heights, BMI, and regions. We measured FeNO levels in 5949 healthy Chinese children and adolescents, FeNO and CaNO levels in 658 participants from 16 provinces of 7 administrative areas in China aged 6-18. All persons were studied after obtaining informed consent from children and their parents. The mean FeNO of 5949 Chinese children and adolescents aged 6-18 years was 14.1 ppb, with a 95% confidence interval of 1-38.1 ppb. The mean FeNO of 658 persons was 6.9 ppb with a 95% upper confidence interval of 15.0 ppb, and the mean CaNO was 3.0 ppb with a 95% upper confidence interval of 11.2 ppb. In the 6-11 age group, age and height were correlated with the logarithm of FeNO (P 
ISSN:1465-993X
1465-9921
1465-993X
DOI:10.1186/s12931-024-02938-4