Rhabdoid melanoma in a harpy eagle (Harpia harpyja)

A 28-year-old male harpy eagle (Harpia harpyja) with a history of anorexia, hyporexia, lethargy, and progressive weight loss was found dead and submitted for post-mortem examination. Gross findings include dark brown discolouration of testes and lungs; the testes were bilaterally enlarged, glistenin...

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Bibliographic Details
Published in:Veterinary and animal science 2021-09, Vol.13, p.100184, Article 100184
Main Authors: Pinzón-Osorio, César Augusto, Ávila-Coy, Jersson, Gomez, Arlen P., Marcela Álvarez-Mira, Diana
Format: Article
Language:English
Subjects:
Immunohistochemistry
Melanocytic neoplasm
Metastases
Raptors
Testicles
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Summary:A 28-year-old male harpy eagle (Harpia harpyja) with a history of anorexia, hyporexia, lethargy, and progressive weight loss was found dead and submitted for post-mortem examination. Gross findings include dark brown discolouration of testes and lungs; the testes were bilaterally enlarged, glistening brown-grey to blackish in appearance, firm, smooth, and multilobulated. The lungs contained a mass with similar features to the testicles, irregularly shaped with multiple nodules. Histology of testis showed round, polygonal and pleomorphic cells, containing melanin pigments and a typical eosinophilic vacuole in their cytoplasm and with severe pleomorphism. An immunohistochemistry panel with Melan-A, vimentin, CK AE1/AE/3, MUM-1 and CD-68 were performed, yielding a positive reaction for Melan-A and vimentin. The morphology of the tumour cells, the presence of melanin pigment and the immunoreactivity for Melan-A and vimentin by the cells led to a diagnosis of rhabdoid melanoma. This is the first case of this pathology in the testis with lung metastasis in a harpy eagle.
ISSN:2451-943X
2451-943X
DOI:10.1016/j.vas.2021.100184