The Role of the Monocyte-to-Lymphocyte Ratio in Acute Ischemic Stroke Patients with Acute Kidney Injury

• Published in: Mediators of inflammation 2022-08, Vol.2022, p.1-8
• Main Authors: Jiang, Fen, Shi, Zhen, Liu, Xiangyang, Xiang, Jiaxuan, Lei, Jie, Yang, Bo, Lei, XiangLi, Li, Xuewei
• Format: Article
• Language: English
• Subjects: Blood platelets; Blood tests; Cardiovascular disease; China; Chronic obstructive pulmonary disease; Coma; Coronary vessels; Creatinine; Diabetes; Health aspects; Hemoglobin; Hypertension; Inflammation; Ischemia; Kidneys; Leukocytes (neutrophilic); Lymphocytes; Medical research; Medicine, Experimental; Monocytes; Mortality; Neutrophils; Patients; Prognosis; Renal replacement therapy; Stroke; Stroke (Disease); Stroke patients; Taiwan; Vein & artery diseases; Ventilators
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2022/7911033

Objective. The objective of the study was to determine if acute kidney injury (AKI) in patients with acute ischemic stroke was associated with the monocyte-to-lymphocyte ratio (MLR) assessed upon admission to the neurology intensive care unit (NICU) (AIS). We also looked into the MLR’s function in predicting hospital mortality in AIS patients. Methods. This retrospective analysis included 595 adult patients with AIS who were hospitalized to the NICU of the First Affiliated Hospital of South China between January 2017 and December 2019. Clinical signs and imaging studies were used to diagnose AIS. KDIGO criteria were used to define AKI. The ratio of monocytes to lymphocytes was used to compute MLR, the ratio of neutrophils to lymphocytes was used to calculate NLR, and the ratio of platelets to lymphocytes was used to calculate PLR. Result. 361 males and 234 women between the ages of 66.27±12.05 years took part in the study. The individuals’ MLR was 0.4729±0.3461 and their neutrophil-to-lymphocyte ratio (NLR) was 8.18±5.45. There were notable disparities in MLR and NLR between the AKI and non-AKI groups (p