Integrating BRAFV600E mutation, ultrasonic and clinicopathologic characteristics for predicting the risk of cervical central lymph node metastasis in papillary thyroid carcinoma

• Published in: BMC cancer 2022-04, Vol.22 (1), p.1-461, Article 461
• Main Authors: Zhang, Zheng, Zhang, Xin, Yin, Yifei, Zhao, Shuangshuang, Wang, Keke, Shang, Mengyuan, Chen, Baoding, Wu, Xincai
• Format: Article
• Language: English
• Subjects: Age; Biopsy, Needle; BRAFV600E mutation; Care and treatment; Cervical cancer; Cervical central lymph node metastases; Clinicopathologic factors; Diagnosis; Dissection; Kinases; Lymph nodes; Lymphatic metastasis; Lymphatic system; Medical prognosis; Metastases; Metastasis; Methods; Multivariate analysis; Mutation; Papillary thyroid carcinoma; Prediction models; Prevention; Risk factors; Statistical analysis; Thyroid; Thyroid cancer; Thyroidectomy; Thyroiditis; Tumors; Ultrasonic features
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-022-09550-z

Background The advantages of prophylactic central lymph node dissection (CLND) for clinically node-negative patients remained a great deal of controversies. Our research was aimed to analyze the relationship between cervical central lymph node metastasis (CLNM) and BRAF.sup.V600E mutation, ultrasonic and clinicopathologic characterizes in papillary thyroid carcinoma (PTC). Methods and materials In current study, a total of 112 consecutive PTC patients who experienced thyroidectomy plus cervical central neck dissection were included in our research. All PTC were pre-operatively analyzed by ultrasonic features, including tumor size, multifocality or not, tumor location, internal components, echogenicity, microcalcification, margins, orientation, taller than wide shape, and internal vascularity. The presence of clinicopathologic factors, including age, sex, T stage, Hashimoto's thyroiditis, and BRAF.sup.V600E mutation was then investigated. Univariate and multivariate analysis were conducted to check into the relationship between predictive factors and cervical CLNM in PTC patients, and then a predictive model was also established. Results Pathologically, 58.0% (65/112) of the PTC patients harbored cervical CLNM. Univariate and multivariate analysis were conducted to identify age < 55 years, tumor size > 10 mm, microcalcification, non-concomitant Hashimoto's thyroiditis and BRAF.sup.V600E mutation were predictive factors for cervical CLNM in PTC. The risk score for cervical CLNM in PTC patients was calculated: risk score = 1.284 x (if age < 55 years) + 1.241 x (if tumor size > 10 mm) + 1.143 x (if microcalcification) - 2.097 x (if concomitant Hashimoto's thyroiditis) + 1.628 x (if BRAF.sup.V600E mutation). Conclusion Age < 55 years old, PTC > 10 mm, microcalcification, non-concomitant Hashimoto's thyroiditis and BRAF.sup.V600E mutation are predictive factors for cervical CLNM. BRAF.sup.V600E mutation by pre-operative US-FNA technology synergized with clinicopathologic and ultrasonic features is expected to guide the appropriate surgical management for PTC patients. Keywords: Papillary thyroid carcinoma, Cervical central lymph node metastases, Ultrasonic features, Clinicopathologic factors, BRAF.sup.V600E mutation