Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle

Forkhead box class O (FOXO) transcription factors regulate whole body energy metabolism, skeletal muscle mass, and substrate switching. FOXO1 and FOXO3 are highly abundant transcription factors, but their precise role in skeletal muscle metabolism has not been fully elucidated. To elucidate the role...

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Bibliographic Details
Published in:Molecular metabolism (Germany) 2019-02, Vol.20, p.79-88
Main Authors: Lundell, Leonidas S., Massart, Julie, Altıntaş, Ali, Krook, Anna, Zierath, Juleen R.
Format: Article
Language:English
Subjects:
Animals
Chemokines - genetics
Chemokines - metabolism
Forkhead Box Protein O1 - genetics
Forkhead Box Protein O1 - metabolism
Forkhead Box Protein O3 - genetics
Forkhead Box Protein O3 - metabolism
FOXO
Glucose - metabolism
Glucose uptake
Inflammation
Male
Medicin och hälsovetenskap
Mice
Mice, Inbred C57BL
Muscle, Skeletal - metabolism
Original
Proto-Oncogene Proteins c-akt - genetics
Proto-Oncogene Proteins c-akt - metabolism
Signal Transduction
Skeletal muscle
TOR Serine-Threonine Kinases - genetics
TOR Serine-Threonine Kinases - metabolism
Transcriptional regulation
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Summary:Forkhead box class O (FOXO) transcription factors regulate whole body energy metabolism, skeletal muscle mass, and substrate switching. FOXO1 and FOXO3 are highly abundant transcription factors, but their precise role in skeletal muscle metabolism has not been fully elucidated. To elucidate the role of FOXO in skeletal muscle, dominant negative (dn) constructs for FOXO1 (FOXO1dn) or FOXO3 (FOXO3dn) were transfected by electroporation into mouse tibialis anterior muscle and glucose uptake, signal transduction, and gene expression profiles were assessed after an oral glucose tolerance test. Results were compared against contralateral control transfected muscle. FOXO1dn and FOXO3dn attenuated glucose uptake (35%, p 
ISSN:2212-8778
2212-8778
DOI:10.1016/j.molmet.2018.09.011