Risk of Plasmodium falciparum infection in south-west Burkina Faso: potential impact of expanding eligibility for seasonal malaria chemoprevention

Burkina Faso has one of the highest malaria burdens in sub-Saharan Africa despite the mass deployment of insecticide-treated nets (ITNs) and use of seasonal malaria chemoprevention (SMC) in children aged up to 5 years. Identification of risk factors for Plasmodium falciparum infection in rural Burki...

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Bibliographic Details
Published in:Scientific reports 2022-01, Vol.12 (1), p.1402-1402, Article 1402
Main Authors: Yaro, Jean Baptiste, Tiono, Alfred B., Ouedraogo, Alphonse, Lambert, Ben, Ouedraogo, Z. Amidou, Diarra, Amidou, Traore, Adama, Lankouande, Malik, Soulama, Issiaka, Sanou, Antoine, Worrall, Eve, Agboraw, Efundem, Sagnon, N’Fale, Ranson, Hilary, Churcher, Thomas S., Lindsay, Steve W., Wilson, Anne L.
Format: Article
Language:English
Subjects:
692/308/174
692/499
692/699/255/1629
Adolescent
Adult
Amodiaquine - therapeutic use
Antigens, Protozoan - blood
Antigens, Protozoan - immunology
Antimalarials - therapeutic use
Burkina Faso - epidemiology
Child
Child, Preschool
Children
Cross-Sectional Studies
Disease transmission
Drug Combinations
Drug Therapy, Combination - methods
Erythrocytes
Female
Humanities and Social Sciences
Humans
Infections
Insecticide-Treated Bednets
Insecticides
Malaria
Malaria, Falciparum - blood
Malaria, Falciparum - epidemiology
Malaria, Falciparum - parasitology
Malaria, Falciparum - prevention & control
Male
Middle Aged
multidisciplinary
Piperonyl butoxide
Plasmodium falciparum
Plasmodium falciparum - immunology
Plasmodium falciparum - isolation & purification
Population studies
Prevalence
Pyrethroids
Pyrimethamine - therapeutic use
Risk Factors
Rural Population
Science
Science (multidisciplinary)
Seasons
Sulfadoxine - therapeutic use
Treatment Outcome
Vector-borne diseases
Young Adult
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Summary:Burkina Faso has one of the highest malaria burdens in sub-Saharan Africa despite the mass deployment of insecticide-treated nets (ITNs) and use of seasonal malaria chemoprevention (SMC) in children aged up to 5 years. Identification of risk factors for Plasmodium falciparum infection in rural Burkina Faso could help to identify and target malaria control measures. A cross-sectional survey of 1,199 children and adults was conducted during the peak malaria transmission season in the Cascades Region of south-west Burkina Faso in 2017. Logistic regression was used to identify risk factors for microscopically confirmed P. falciparum infection. A malaria transmission dynamic model was used to determine the impact on malaria cases averted of administering SMC to children aged 5–15 year old. P. falciparum prevalence was 32.8% in the study population. Children aged 5 to 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-05056-7