Latilactobacillus sakei Wikim0066 Protects Skin through MMP Regulation on UVB-Irradiated In Vitro and In Vivo Model

Ultraviolet (UV) B exposure induces wrinkle formation, collagen fiber breakdown, and transepidermal water loss (TEWL). UVB irradiation induces the expression of mitogen-activated protein kinase (MAPK), activator protein 1 (AP-1), and nuclear factor kappa B (NF-κB), which affect the expression of mat...

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Bibliographic Details
Published in:Nutrients 2023-02, Vol.15 (3), p.726
Main Authors: Park, Jeong-Yong, Lee, Ji Yeon, Kim, YongGyeong, Kang, Chang-Ho
Format: Article
Language:English
Subjects:
Activator protein 1
Aging
Animals
Cell culture
Collagen
Cytokines
Cytotoxicity
Fatty acids
Fibroblasts
Hairless
Interstitial collagenase
Irradiation
Kinases
Laboratory animals
Latilactobacillus sakei
MAP kinase
Matrix metalloproteinase
Matrix metalloproteinases
Mice
Mice, Hairless
Mitogen-Activated Protein Kinases - metabolism
NF-kappa B - metabolism
NF-κB protein
Oral administration
Plant Extracts - pharmacology
Probiotics
Procollagen
Proteins
Radiation
Skin - metabolism
Skin Aging
Transcription Factor AP-1 - metabolism
Transcription factors
Tumor necrosis factor-TNF
ultraviolet B
Ultraviolet Rays - adverse effects
wrinkle
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Summary:Ultraviolet (UV) B exposure induces wrinkle formation, collagen fiber breakdown, and transepidermal water loss (TEWL). UVB irradiation induces the expression of mitogen-activated protein kinase (MAPK), activator protein 1 (AP-1), and nuclear factor kappa B (NF-κB), which affect the expression of matrix metalloproteinases (MMP). We confirmed the effects of wikim0066 (wikim0066) on UVB-irradiated Hs68 cells and HR-1 hairless mice cells. wikim0066 restored the production of type I procollagen by regulating the expression of MMP-1 and -3, MAPK, AP-1, and NF-κB in UVB-irradiated Hs68 cells and HR-1 mice. Oral administration of wikim0066 alleviates wrinkle formation, epidermal thickness, and TEWL in UVB-irradiated HR-1 hairless mice. These results indicated that wikim0066 has the potential to prevent UVB-induced wrinkle formation.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15030726