A Case of Purpura Annularis Telangiectodes of Majocchi after Anti-SARS-CoV-2 Pfizer-BioNTech Vaccine: Is There an Association?

The advent of vaccines has drastically reduced the incidence, morbidity, and mortality related to COVID-19, and with the increase in the number of vaccinated subjects, there have been reports of some adverse events, including skin reactions. In this paper, we report a clinical case of Purpura Annula...

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Published in:Vaccines (Basel) 2022-11, Vol.10 (11), p.1972
Main Authors: Ambrogio, Francesca, Laface, Carmelo, Sbarra, Giorgia, Filotico, Raffaele, Ranieri, Girolamo, Barlusconi, Chiara, De Marco, Aurora, Cazzato, Gerardo, Bonamonte, Domenico, Romita, Paolo, Foti, Caterina
Format: Article
Language:English
Subjects:
anti-SARS-CoV-2 vaccine
Blood
Blood vessels
Capillaries
Case Report
Conflicts of interest
Coronaviruses
COVID-19
COVID-19 vaccines
Development and progression
Erythema
Informed consent
Majocchi’s disease
Morbidity
mRNA vaccine
pigmented purpuric dermatoses
Public health
Purpura
Purpura (Pathology)
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Skin diseases
Vaccines
Viral diseases
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Summary:The advent of vaccines has drastically reduced the incidence, morbidity, and mortality related to COVID-19, and with the increase in the number of vaccinated subjects, there have been reports of some adverse events, including skin reactions. In this paper, we report a clinical case of Purpura Annularis Telangiectodes of Majocchi following a third-dose administration of the Pfizer-BioNTech COVID-19 vaccine. Almost 30 days after the third dose, the patient presented erythematous annular patches on the lower limbs with purpuric peripheral areas and a central clearing with no other symptoms. A dermoscopic examination showed capillaritis, reddish-brown dot-clods on a coppery-red background caused by leaky capillaries. To date, the causes of Majocchi’s disease are not well-defined; in the literature, three vaccination-related cases have been reported: one after a flu vaccination and two after an anti-SARS-CoV-2 one. Dermatologists should be trained to promptly recognize these clinical manifestations after vaccination, which will likely become a common finding in daily clinical practice, especially given the large diffusion of SARS-CoV-2 vaccinations.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines10111972