Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex

The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator...

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Bibliographic Details
Published in:Frontiers in molecular neuroscience 2018-07, Vol.11, p.247-247
Main Authors: Miao, Nan, Bian, Shan, Lee, Trevor, Mubarak, Taufif, Huang, Shiying, Wen, Zhihong, Hussain, Ghulam, Sun, Tao
Format: Article
Language:English
Subjects:
antagonist
Cell cycle
Cerebral cortex
Dkk1 protein
Embryos
Frizzled protein
Frizzled-related protein
Frizzled-related protein 1
Gene expression
Hybridization
Ligands
Microcephaly
Nervous system
neural progenitors
Neural stem cells
Neurogenesis
Neuromodulation
Neurons
Neuroscience
Sfrp1
Wnt protein
Wnt7a
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Summary:The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator of Wnts, are co-expressed in mouse embryonic cortical neural progenitors (NPs). Knockout of Wnt7a in mice causes microcephaly due to reduced NP population and neurogenesis, and Sfrp1 has an opposing effect compared to Wnt7a. Similar to Dkk1, Sfrp1 decreases the Wnt1 and Wnt7a activity . Our results suggest that Wnt7a and Sfrp1 play opposite roles to ensure proper NP progeny in the developing cortex.
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2018.00247