Cerebral small vessel disease, cardiovascular risk factors, and future walking speed in old age: a population-based cohort study

The purpose of this study was to examine the associations between combined and individual cerebral small vessel disease (cSVD) markers on future walking speed over 9 years; and to explore whether these associations varied by the presence of cardiovascular risk factors (CRFs). This population-based c...

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Bibliographic Details
Published in:BMC neurology 2021-12, Vol.21 (1), p.496-496, Article 496
Main Authors: Heiland, Emerald G, Welmer, Anna-Karin, Kalpouzos, Grégoria, Laveskog, Anna, Wang, Rui, Qiu, Chengxuan
Format: Article
Language:English
Subjects:
Age
Aged
Body weight
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular risk factors
Care and treatment
Cerebral small vessel disease
Cerebral Small Vessel Diseases - diagnostic imaging
Cerebral Small Vessel Diseases - epidemiology
Cholesterol
Cognitive ability
Cohort analysis
Cohort Studies
Data collection
Dementia
Demography
Diabetes mellitus
Diagnosis
Disease
Health aspects
Heart Disease Risk Factors
Humans
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI)
Male
Medical imaging
Medicin/Teknik
Medicine/Technology
Methods
Older people
Overweight
Physical function
Population
Population studies
Population-based cohort study
Population-based studies
Risk Factors
Substantia alba
Vascular diseases
Walking
Walking Speed
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Summary:The purpose of this study was to examine the associations between combined and individual cerebral small vessel disease (cSVD) markers on future walking speed over 9 years; and to explore whether these associations varied by the presence of cardiovascular risk factors (CRFs). This population-based cohort study included 331 adults, aged ≥60 years, without limitation in walking speed (≥0.8 m/s). At baseline, cSVD markers, including white matter hyperintensities (WMH), lacunes, and perivascular spaces (PVS), were assessed on magnetic resonance imaging. The modifiable CRFs (physical inactivity, heavy alcohol consumption, smoking, hypertension, high total cholesterol, diabetes, and overweight/obese) were combined into a score. The association between baseline cSVD markers and the decline in walking speed was examined using linear mixed-effects models, whereas Cox proportional hazards models were used to estimate the association with walking speed limitation (defined as
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-021-02529-6