Current Role and Potential of Triple Quadrupole Mass Spectrometry in Biomedical Research and Clinical Applications

Mass-spectrometry-based assays nowadays play an essential role in biomedical research and clinical applications. There are different types of commercial mass spectrometers on the market today, and triple quadrupole (QqQ) is one of the time-honored systems. Here, we overview the main areas of QqQ app...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-12, Vol.29 (23), p.5808
Main Authors: Tsakalof, Andreas, Sysoev, Alexey A, Vyatkina, Kira V, Eganov, Alexander A, Eroshchenko, Nikolay N, Kiryushin, Alexey N, Adamov, Alexey Yu, Danilova, Elena Yu, Nosyrev, Alexander E
Format: Article
Language:English
Subjects:
Biomedical research
Biomedical Research - methods
Boolean
Chromatography
clinical applications
Congenital diseases
Disease prevention
Drug Monitoring - methods
Endocrine disorders
Hormones
Humans
Immunoassay
Laboratories
Mass spectrometry
Mass Spectrometry - methods
Medical research
Medical screening
Medicine, Experimental
Metabolism
Methods
Review
Scientific imaging
Spectrum analysis
Steroids
tandem mass spectrometry
Technology application
Trends
triple quadrupole
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Summary:Mass-spectrometry-based assays nowadays play an essential role in biomedical research and clinical applications. There are different types of commercial mass spectrometers on the market today, and triple quadrupole (QqQ) is one of the time-honored systems. Here, we overview the main areas of QqQ applications in biomedicine and assess the current level, evolution, and trends in the use of QqQ in these areas. Relevant data were extracted from the Scopus database using the specified terms and Boolean operators defined for each field of the QqQ application. We also discuss the recent advances in QqQ and QqQ-based analytical platforms, which promote the clinical application of these systems, and explain the indicated substantial increase in triple quadrupole use in biomedicine. The number of biomedical studies utilizing QqQ increased 2-3 times this decade. Triple quadrupole is most intensively used in the field of endocrine research and testing. On the contrary, the relative rate of immunoassay utilization-a major competitor of chromatography-mass spectrometry-decreased in this area as well as its use within Therapeutic drug monitoring (TDM) and forensic toxicology. Nowadays, the applications of high-resolution accurate mass (HRAM) mass spectrometers in the investigated areas represent only a small fraction of the total amount of research using mass spectrometry; however, their application substantially increased during the last decade in the untargeted search for new biomarkers.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29235808