Impact of Persistent Anemia on Systemic Inflammation and Tuberculosis Outcomes in Persons Living With HIV

Tuberculosis (TB) is associated with systemic inflammation and anemia, which are aggravated in persons living with HIV (PLWH). Here, we characterized the dynamics of hemoglobin levels in PLWH coinfected with TB undergoing antitubercular therapy (ATT). We also examined the relationships between anemi...

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Bibliographic Details
Published in:Frontiers in immunology 2020-09, Vol.11, p.588405-588405
Main Authors: Demitto, Fernanda O, Araújo-Pereira, Mariana, Schmaltz, Carolina A, Sant'Anna, Flávia M, Arriaga, María B, Andrade, Bruno B, Rolla, Valeria C
Format: Article
Language:English
Subjects:
anemia
HIV
Immunology
inflammation
treatment outcome
tuberculosis
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Summary:Tuberculosis (TB) is associated with systemic inflammation and anemia, which are aggravated in persons living with HIV (PLWH). Here, we characterized the dynamics of hemoglobin levels in PLWH coinfected with TB undergoing antitubercular therapy (ATT). We also examined the relationships between anemia and systemic inflammatory disturbance as well as the association between persistent anemia and unfavorable clinical outcomes. Data on several blood biochemical parameters and on blood cell counts were retrospectively analyzed in a cohort of 256 TB/HIV patients from Brazil during 180 days of ATT. Multidimensional statistical analyses were employed to profile systemic inflammation of patients stratified by anemia status (hemoglobin levels
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.588405