Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature

BACKGROUND: Placental site trophoblastic tumor (PSTT) is a rare and unique form of gestational trophoblastic disease (GTD). This tumor represents a neoplastic transformation of intermediate trophoblastic cells. We document a case of long term remission in a patient with metastatic PSTT. CASE PRESENT...

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Bibliographic Details
Published in:World journal of surgical oncology 2005-06, Vol.3 (1), p.34-34, Article 34
Main Authors: Behtash, Nadereh, Ghaemmaghami, Fatemeh, Hasanzadeh, Malihe
Format: Article
Language:English
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Case Report
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Summary:BACKGROUND: Placental site trophoblastic tumor (PSTT) is a rare and unique form of gestational trophoblastic disease (GTD). This tumor represents a neoplastic transformation of intermediate trophoblastic cells. We document a case of long term remission in a patient with metastatic PSTT. CASE PRESENTAION: A 27-year-old patient with metastatic PSTT was treated with combination therapy (chemotherapy and surgery). Patient is alive after 10 years without any evidence of recurrence. Literature on PSTT was searched using Medline and cross references, and pertinent articles were reviewed. CONCLUSION: With surgery and chemotherapy it is possible to achieve long-term remission in metastatic PSTT. Only a handful of previously reported cases with prolonged remission had been treated with the described combined chemotherapy and surgical approach. We suggest that this approach may be recommended for metastatic PSTT.
ISSN:1477-7819
1477-7819
DOI:10.1186/1477-7819-3-34