Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19

Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interviews, neurop...

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Bibliographic Details
Published in:Annals of Clinical and Translational Neurology 2022-02, Vol.9 (2), p.221-226
Main Authors: Apple, Alexandra C., Oddi, Alexis, Peluso, Michael J., Asken, Breton M., Henrich, Timothy J., Kelly, J. Daniel, Pleasure, Samuel J., Deeks, Steven G., Allen, Isabel Elaine, Martin, Jeffrey N., Ndhlovu, Lishomwa C., Miller, Bruce L., Stephens, Melanie L., Hellmuth, Joanna
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Attention deficit hyperactivity disorder
Brain research
Brief Communication
Brief Communications
Cerebrospinal fluid
Cerebrospinal Fluid - virology
Cognition - physiology
Cognitive ability
Coronaviruses
COVID-19 - cerebrospinal fluid
COVID-19 - physiopathology
COVID-19 vaccines
Diagnostic tests
Disease Progression
Drug use
Ethnicity
Female
Gender
Hispanic Americans
HIV
Hospitalization
Human immunodeficiency virus
Humans
Illnesses
Infections
Male
Memory
Middle Aged
Neuropsychology
Pathogenesis
Research Personnel
Risk Factors
SARS-CoV-2 - pathogenicity
Severe acute respiratory syndrome coronavirus 2
Traumatic brain injury
Young Adult
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Description
Summary:Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%). Delayed onset of cognitive PASC occurred in 43% and associated with younger age. Cognitive PASC participants had a higher number of pre‐existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls. Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis.
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.51498