Genetic Loss of miR-205 Causes Increased Mammary Gland Development

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and matura...

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Bibliographic Details
Published in:Non-coding RNA 2023-12, Vol.10 (1), p.4
Main Authors: Cataldo, Alessandra, Cheung, Douglas G, Hagan, John P, Fassan, Matteo, Sandhu-Deol, Sukhinder, Croce, Carlo M, Di Leva, Gianpiero, Iorio, Marilena V
Format: Article
Language:English
Subjects:
Breast cancer
Cell culture
Cell growth
Communication
Ethylenediaminetetraacetic acid
Females
Kinases
Mammary gland
MicroRNA
MicroRNAs
miRNA
Neomycin
Physiology
Stem cells
Transgenic animals
Tumors
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Summary:MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205 female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer.
ISSN:2311-553X
2311-553X
DOI:10.3390/ncrna10010004