Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector Anopheles coluzzii

Information on common markers of metabolic resistance in malaria vectors from countries sharing similar eco-climatic characteristics can facilitate coordination of malaria control. Here, we characterized populations of the major malaria vector Anopheles coluzzii from Sahel region, spanning four sub-...

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Bibliographic Details
Published in:BMC biology 2023-05, Vol.21 (1), p.125-23, Article 125
Main Authors: Ibrahim, Sulaiman S, Muhammad, Abdullahi, Hearn, Jack, Weedall, Gareth D, Nagi, Sanjay C, Mukhtar, Muhammad M, Fadel, Amen N, Mugenzi, Leon J, Patterson, Edward I, Irving, Helen, Wondji, Charles S
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acetylcholinesterase - genetics
Adenine
Analysis
Animals
Animals, Genetically Modified
Anopheles
Anopheles - genetics
Anopheles coluzzii
Automobile drivers
Binding sites
Biocompatibility
Cameroon
Causes of
Channel gating
Chromosome rearrangements
Chromosomes
Control
Cross-resistance
Cypermethrin
DDT
Drosophila melanogaster
Epidemiology
Flies
Forkhead protein
Gene deletion
Gene expression
Genes
Genetic aspects
Genetic engineering
Genetic polymorphisms
Genetic transcription
Genomes
Glutathione
Glutathione transferase
Health aspects
High frequencies
Hydrolysis
Insecticide resistance
Insecticide Resistance - genetics
Insecticides
Insecticides - pharmacology
Insects as carriers of disease
Inversions
Laboratories
Malaria
Malaria - prevention & control
Metabolic
Metabolism
Mortality
Mosquito Vectors - genetics
Mosquitoes
Mutation
Nigeria
Nucleotides
Permethrin
Pesticide resistance
Physiological aspects
Populations
Proteins
Pyrethroid
Pyrethroids
Risk factors
Sahel
Sodium channels (voltage-gated)
Sub-Saharan Africa
Vector-borne diseases
Vectors
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Summary:Information on common markers of metabolic resistance in malaria vectors from countries sharing similar eco-climatic characteristics can facilitate coordination of malaria control. Here, we characterized populations of the major malaria vector Anopheles coluzzii from Sahel region, spanning four sub-Saharan African countries: Nigeria, Niger, Chad and Cameroon. Genome-wide transcriptional analysis identified major genes previously implicated in pyrethroid and/or cross-resistance to other insecticides, overexpressed across the Sahel, including CYP450s, glutathione S-transferases, carboxylesterases and cuticular proteins. Several, well-known markers of insecticide resistance were found in high frequencies-including in the voltage-gated sodium channel (V402L, I940T, L995F, I1527T and N1570Y), the acetylcholinesterase-1 gene (G280S) and the CYP4J5-L43F (which is fixed). High frequencies of the epidemiologically important chromosomal inversion polymorphisms, 2La, 2Rb and 2Rc, were observed (~80% for 2Rb and 2Rc). The 2La alternative arrangement is fixed across the Sahel. Low frequencies of these inversions (
ISSN:1741-7007
1741-7007
DOI:10.1186/s12915-023-01610-5