Recent progress in targeted delivery vectors based on biomimetic nanoparticles

Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs) since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological vectors including cell membranes, extracellular vesicles (EVs), and viruses are considered promising candidates for targe...

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Bibliographic Details
Published in:Signal transduction and targeted therapy 2021-06, Vol.6 (1), p.225-25, Article 225
Main Authors: Chen, Li, Hong, Weiqi, Ren, Wenyan, Xu, Ting, Qian, Zhiyong, He, Zhiyao
Format: Article
Language:English
Subjects:
631/154/152
631/61/2049
Biomimetic Materials - therapeutic use
Cancer Research
Cell Biology
Drug Carriers - chemistry
Drug Carriers - therapeutic use
Drug Delivery Systems
Extracellular vesicles
Extracellular Vesicles - chemistry
Extracellular Vesicles - genetics
Humans
Internal Medicine
Medicine
Medicine & Public Health
Nanoparticles
Nanoparticles - therapeutic use
Nanotechnology
Oncology
Pathology
Review
Review Article
Vectors (Biology)
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Summary:Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs) since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological vectors including cell membranes, extracellular vesicles (EVs), and viruses are considered promising candidates for targeted delivery owing to their biocompatibility and biodegradability. BNPs, the integration of biological vectors and functional agents, are anticipated to load cargos or camouflage synthetic nanoparticles to achieve targeted delivery. Despite their excellent intrinsic properties, natural vectors are deliberately modified to endow multiple functions such as good permeability, improved loading capability, and high specificity. Through structural modification and transformation of the vectors, they are pervasively utilized as more effective vehicles that can deliver contrast agents, chemotherapy drugs, nucleic acids, and genes to target sites for refractory disease therapy. This review summarizes recent advances in targeted delivery vectors based on cell membranes, EVs, and viruses, highlighting the potential applications of BNPs in the fields of biomedical imaging and therapy industry, as well as discussing the possibility of clinical translation and exploitation trend of these BNPs.
ISSN:2059-3635
2095-9907
2059-3635
DOI:10.1038/s41392-021-00631-2