Association between serum 25- hydroxyvitamin D and albuminuiria in middle-aged and older Chinese patients with type 2 diabetes

Objective The objective was to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) level and albuminuiria in middle-aged and older patients with type 2 diabetes of Gansu Province. Methods Data pertaining to 380 in-patients with type 2 diabetes were collected. Subjects were classifi...

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Published in:BMC endocrine disorders 2023-09, Vol.23 (1), p.1-189, Article 189
Main Authors: Zhang, Luyan, Guo, Qian, Xu, Yanjia, Wei, Wenzhen, Wang, Yu
Format: Article
Language:English
Subjects:
25- hydroxyvitamin D
Age groups
Albuminuiria
Alfacalcidol
Analysis
Calcifediol
Creatinine
Diabetes
Diabetes mellitus (non-insulin dependent)
Hospitals
Immunoassay
Kidney diseases
Middle age
Normal distribution
Older people
Type 2 diabetes
Variables
Vitamin D
Vitamin deficiency
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Summary:Objective The objective was to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) level and albuminuiria in middle-aged and older patients with type 2 diabetes of Gansu Province. Methods Data pertaining to 380 in-patients with type 2 diabetes were collected. Subjects were classified groups based on gender,age,25(OH)D,BMI and UACR.Serum 25(OH)D and other clinical characteristics among various UACR groups were compared.The relationship between albuminuiria and 25(OH)D was analyzed. Results Out of the 380 subjects, 83.4%were classified as vitamin D deficiency, 14.5%were classified as vitamin D insufficiency, while 2.1% were classified as vitamin D sufficiency. Among the participants,41% had albuminuria (microalbuminuria,28.7%;macroalbuminuria,12.3%).The prevalence of 25(OH)D deficiency in the albuminuria group(84.6%) was significantly higher than that in the normoalbuminuria group(82.6%)(Mann-Whitney U test:Z = -3.86,P = 0.000); patients with macroalbuminuria had the highest prevalence of 25(OH)D deficiency (91.5%; P < 0.01 versus normoalbuminuria).A binary logistic analysis demonstrated that 25(OH)D were protective factors for albuminuria. Conclusions The prevalence of vitamin D deficiency in patients with albuminuria was overtly higher than that in patients without albuminuria among middle-aged and older adults with type 2 diabetes. Keywords: 25- hydroxyvitamin D, Albuminuiria, Diabetes
ISSN:1472-6823
1472-6823
DOI:10.1186/s12902-023-01440-0