Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis

Rupr. is medicinal plant used for supplemental therapy of various diseases based on their positive biological activities. The aim of this study was evaluated the main metabolite, safety of application and anticancer potential. Berberine was determined by HPLC as main alkaloid. Harmful character was...

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Published in:Life (Basel, Switzerland) Switzerland), 2022-05, Vol.12 (5), p.767
Main Authors: Balážová, Ľudmila, Kurhajec, Slavomír, Kello, Martin, Bedlovičová, Zdenka, Zigová, Martina, Petrovová, Eva, Beňová, Katarína, Mojžiš, Ján, Eftimová, Jarmila
Format: Article
Language:English
Subjects:
Angiogenesis
Antiangiogenics
Anticancer properties
Antiproliferatives
Artemia
Bark
Berberine
Blood vessels
CAM
cancer
Cancer therapies
Cell cycle
Cell growth
Embryos
Herbal medicine
High-performance liquid chromatography
In vivo methods and tests
Irritation
Liquid chromatography
Medicinal plants
Metabolites
Phellodendron amurense
Polyphenols
Prostate cancer
Tumors
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Summary:Rupr. is medicinal plant used for supplemental therapy of various diseases based on their positive biological activities. The aim of this study was evaluated the main metabolite, safety of application and anticancer potential. Berberine was determined by HPLC as main alkaloid. Harmful character was determined by irritation test in ovo. The potential cancerogenic effect was studied in vitro on a cellular level, in ovo by CAM assay and in vivo on whole organism . Extract from the bark of showed antiproliferative and antiangiogenic effects. The results of our work showed promising anticancer effects based also on the inhibition of angiogenesis with minimum negative effects.
ISSN:2075-1729
2075-1729
DOI:10.3390/life12050767