Bio-physiological susceptibility of the brain, heart, and lungs to systemic ischemia reperfusion and hyperoxia-induced injury in post-cardiac arrest rats

Cardiac arrest (CA) patients suffer from systemic ischemia–reperfusion (IR) injury leading to multiple organ failure; however, few studies have focused on tissue-specific pathophysiological responses to IR-induced oxidative stress. Herein, we investigated biological and physiological parameters of t...

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Published in:Scientific reports 2023-02, Vol.13 (1), p.3419-3419, Article 3419
Main Authors: Aoki, Tomoaki, Wong, Vanessa, Endo, Yusuke, Hayashida, Kei, Takegawa, Ryosuke, Okuma, Yu, Shoaib, Muhammad, Miyara, Santiago J., Yin, Tai, Becker, Lance B., Shinozaki, Koichiro
Format: Article
Language:English
Subjects:
692/308/1426
692/308/409
692/308/575
Animals
Apoptosis
Asphyxia
Brain
Brain - pathology
Cardiac arrest
Cardiopulmonary Resuscitation
Cerebral blood flow
Disease Models, Animal
Echocardiography
Gene expression
Heart
Heart Arrest - complications
Humanities and Social Sciences
Hyperoxia
Hyperoxia - complications
Inflammation
Ischemia
Lung
Lungs
Mechanical ventilation
multidisciplinary
Oxidative stress
Oxygen
Physiology
Rats
Reperfusion
Reperfusion Injury - complications
Reperfusion Injury - pathology
Respiratory function
Science
Science (multidisciplinary)
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Summary:Cardiac arrest (CA) patients suffer from systemic ischemia–reperfusion (IR) injury leading to multiple organ failure; however, few studies have focused on tissue-specific pathophysiological responses to IR-induced oxidative stress. Herein, we investigated biological and physiological parameters of the brain and heart, and we particularly focused on the lung dysfunction that has not been well studied to date. We aimed to understand tissue-specific susceptibility to oxidative stress and tested how oxygen concentrations in the post-resuscitation setting would affect outcomes. Rats were resuscitated from 10 min of asphyxia CA. Mechanical ventilation was initiated at the beginning of cardiopulmonary resuscitation. We examined animals with or without CA, and those were further divided into the animals exposed to 100% oxygen (CA_Hypero) or those with 30% oxygen (CA_Normo) for 2 h after resuscitation. Biological and physiological parameters of the brain, heart, and lungs were assessed. The brain and lung functions were decreased after CA and resuscitation indicated by worse modified neurological score as compared to baseline (222 ± 33 vs. 500 ± 0, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-30120-1