Hepatic Silicone Granulomas Secondary to Ruptured Breast Implants: A Report of Two Cases

The differential diagnosis of hepatic granulomas is vast and includes infections, drugs, immunologic diseases, foreign material exposure, and neoplasia. Silicone, whether directly injected into tissues or used as a filler in breast implants, is known to cause localized granulomatous reactions. It ca...

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Bibliographic Details
Published in:Case reports in hepatology 2019-01, Vol.2019 (2019), p.1-4
Main Authors: Rustgi, Vinod, Fyfe, Billie, Zaldana, Francisco, Catalano, Carolyn, John, Tina, Gordon, Ronald, Anand, Kapil, Hudacko, Rachel, Katz, Henry J.
Format: Article
Language:English
Subjects:
Abdomen
Anemia
Bile
Breast implants
Case Report
Case reports
Gastroenterology
Granulomas
Hepatitis
Hepatology
Inflammation
Liver diseases
Medical imaging
Microscopy
Patients
Phosphatase
Plastic surgery
Rheumatology
Sarcoidosis
Silicones
Stains & staining
Transplants & implants
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Summary:The differential diagnosis of hepatic granulomas is vast and includes infections, drugs, immunologic diseases, foreign material exposure, and neoplasia. Silicone, whether directly injected into tissues or used as a filler in breast implants, is known to cause localized granulomatous reactions. It can also migrate to other anatomic locations resulting in granulomatous inflammation at a distance. We report two cases of unsuspected hepatic silicone granulomas in patients undergoing liver biopsy for isolated elevated alkaline phosphatase levels, both with a history of ruptured breast implants. These cases highlight the need for awareness of hepatic silicone granulomas as an etiology of elevated liver enzymes in patients with a history of surgical interventions utilizing silica, such as cosmetic surgery.
ISSN:2090-6587
2090-6595
DOI:10.1155/2019/7348168