Association Between Elevated Blood Eosinophils and Chronic Kidney Disease Progression: Analyses of a Large United States Electronic Health Records Database

Blood eosinophils can increase in response to infection, inflammation, and hypersensitivity reactions, yet their involvement in the progression of chronic kidney disease (CKD) is poorly understood. This study explores the relationship between blood eosinophils and CKD progression among patients in a...

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Published in:International journal of nephrology and renovascular disease 2023-01, Vol.16, p.269-280
Main Authors: Kielar, Danuta, Jones, Andrew M, Wang, Xia, Stirnadel-Farrant, Heide, Katial, Rohit K, Bansal, Abhinav, Garg, Manu, Sharma, Chandrakant, Thakar, Shubhankar, Ye, Qin
Format: Article
Language:English
Subjects:
Analysis
Anemia
Chronic kidney failure
Development and progression
Electronic records
eosinophilic inflammation
glomerular filtration rate
Health aspects
Hypertension
Medical records
Medical research
Medicine, Experimental
Original Research
Pharmaceutical industry
renal insufficiency
Risk factors
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cited_by cdi_FETCH-LOGICAL-c552t-475485e2e93ee02ac50b0785b9c4375ec6fb4963483450eb68b87587f1981f1d3
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container_title International journal of nephrology and renovascular disease
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creator Kielar, Danuta
Jones, Andrew M
Wang, Xia
Stirnadel-Farrant, Heide
Katial, Rohit K
Bansal, Abhinav
Garg, Manu
Sharma, Chandrakant
Thakar, Shubhankar
Ye, Qin
description Blood eosinophils can increase in response to infection, inflammation, and hypersensitivity reactions, yet their involvement in the progression of chronic kidney disease (CKD) is poorly understood. This study explores the relationship between blood eosinophils and CKD progression among patients in a real-world setting. This retrospective study analyzed data obtained from the Optum de-identified electronic health records dataset in the United States. Patients diagnosed with CKD stage 3 or 4 (International Classification of Diseases diagnosis code or estimated glomerular filtration rate [eGFR]
doi_str_mv 10.2147/IJNRD.S431375
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We found that high eosinophilic levels (bEOS ≥300 cells/µL) were associated with CKD progression from stage 3 to stages 4 or 5 (hazard ratio [HR] ranging from 1.30 to 1.50) and from stages 4 to 5 (HR ranging from 1.28 to 1.50). Among patients with CKD progression, those with blood eosinophils ≥300 cells/µL appeared to have a relatively lower eGFR, higher all-cause mortality, and reduced time to CKD progression and death than those with &lt;300 cells/µL. Factors including sex, race, hypertension, anemia, and treatments for cardiovascular and hematopoietic drugs were associated with CKD progression. Elevated eosinophils may increase the risk for CKD progression. 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We found that high eosinophilic levels (bEOS ≥300 cells/µL) were associated with CKD progression from stage 3 to stages 4 or 5 (hazard ratio [HR] ranging from 1.30 to 1.50) and from stages 4 to 5 (HR ranging from 1.28 to 1.50). Among patients with CKD progression, those with blood eosinophils ≥300 cells/µL appeared to have a relatively lower eGFR, higher all-cause mortality, and reduced time to CKD progression and death than those with &lt;300 cells/µL. Factors including sex, race, hypertension, anemia, and treatments for cardiovascular and hematopoietic drugs were associated with CKD progression. Elevated eosinophils may increase the risk for CKD progression. 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subjects Analysis
Anemia
Chronic kidney failure
Development and progression
Electronic records
eosinophilic inflammation
glomerular filtration rate
Health aspects
Hypertension
Medical records
Medical research
Medicine, Experimental
Original Research
Pharmaceutical industry
renal insufficiency
Risk factors
title Association Between Elevated Blood Eosinophils and Chronic Kidney Disease Progression: Analyses of a Large United States Electronic Health Records Database
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