miR-429 expression in bladder cancer and its correlation with tumor behavior and clinical outcome

We previously showed that microRNA-429 (miR-429) played an important role in epithelial–mesenchymal transition (EMT) of urothelial cell carcinoma of the bladder. We herein evaluated the expression of miR-429 in bladder cancer and its potential relevance to clinicopathological characteristics and pat...

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Bibliographic Details
Published in:The Kaohsiung journal of medical sciences 2018-06, Vol.34 (6), p.335-340
Main Authors: Wu, Chia-Lun, Ho, Jar-Yi, Hung, Shun-Hsing, Yu, Dah-Shyong
Format: Article
Language:English
Subjects:
Bladder cancer
Cancer survival rate
MicroRNA-429
Tumor behavior
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Summary:We previously showed that microRNA-429 (miR-429) played an important role in epithelial–mesenchymal transition (EMT) of urothelial cell carcinoma of the bladder. We herein evaluated the expression of miR-429 in bladder cancer and its potential relevance to clinicopathological characteristics and patient survival. Relative expression levels of miR-429 in surgical bladder cancer tissue specimens obtained from 76 patients with bladder cancer were measured by chromogenic in situ hybridization. miR-429 expression was significantly higher in specimens from alive patients than expired patients in both of 5-year overall survival (OS) (0.59 ± 0.09 vs. 0.27 ± 0.12; p 
ISSN:1607-551X
2410-8650
DOI:10.1016/j.kjms.2018.01.001