Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos Liquid-phase microextraction (LPME): fundamentals and applications to the analysis of drugs in biological samples

The analysis of drugs and metabolites in biological fluids usually requires extraction procedures to achieve sample clean-up and analyte preconcentration. Commonly, extraction procedures are performed using liquid-liquid extraction or solid-phase extraction. Nevertheless, these extraction techniques...

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Bibliographic Details
Published in:Química nova 2008-01, Vol.31 (3), p.637-644
Main Authors: Anderson Rodrigo Moraes de Oliveira, Igor Rafael dos Santos Magalhães, Fernando José Malagueño de Santana, Pierina Sueli Bonato
Format: Article
Language:English
Subjects:
biological samples
drug analysis
liquid-phase microextraction
Online Access:Get full text
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Summary:The analysis of drugs and metabolites in biological fluids usually requires extraction procedures to achieve sample clean-up and analyte preconcentration. Commonly, extraction procedures are performed using liquid-liquid extraction or solid-phase extraction. Nevertheless, these extraction techniques are considered to be time-consuming and require a large amount of organic solvents. On this basis, microextraction techniques have been developed. Among them, liquid-phase microextraction has been standing out. This review describes the liquid-phase microextraction technique based on hollow fibers as a novel and promising alternative in sample preparation prior to chromatographic or electrophoretic analysis. The basic concepts related to this technique and its applicability in extraction of drugs are discussed.
ISSN:0100-4042
1678-7064
DOI:10.1590/S0100-40422008000300031