Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles and to link drug concentrations to clinical outco...

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Bibliographic Details
Published in:Marine drugs 2018-07, Vol.16 (7), p.246
Main Authors: van Andel, Lotte, Rosing, Hilde, Schellens, Jan Hm, Beijnen, Jos H
Format: Article
Language:English
Subjects:
Analytical methods
bioanalysis
Cancer
Cancer therapies
chromatography
Detection
Drugs
marine-derived drugs
Pharmacology
Pretreatment
Profiles
Review
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Summary:The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles and to link drug concentrations to clinical outcomes. This review outlines the different analytical methods that have been described for marine-derived drugs in cancer treatment hitherto. It focuses on the major parts of the bioanalytical technology, including sample type, sample pre-treatment, separation, detection, and quantification.
ISSN:1660-3397
1660-3397
DOI:10.3390/md16070246