A novel photosynthetic biologic topical gel for enhanced localized hyperoxygenation augments wound healing in peripheral artery disease

Peripheral artery disease and the associated ischemic wounds are substantial causes of global morbidity and mortality, affecting over 200 million people worldwide. Although advancements have been made in preventive, pharmacologic, and surgical strategies to treat this disease, ischemic wounds, a con...

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Bibliographic Details
Published in:Scientific reports 2022-06, Vol.12 (1), p.10028-10028, Article 10028
Main Authors: Zhu, Yuanjia, Jung, Jinsuh, Anilkumar, Shreya, Ethiraj, Sidarth, Madira, Sarah, Tran, Nicholas A., Mullis, Danielle M., Casey, Kerriann M., Walsh, Sabrina K., Stark, Charles J., Venkatesh, Akshay, Boakye, Alexander, Wang, Hanjay, Woo, Y. Joseph
Format: Article
Language:English
Subjects:
692/4019/592/75
692/699/75/593
Animal models
Biological Products
Carbon dioxide
Gels
Humanities and Social Sciences
Humans
Ischemia
Light sources
Morbidity
multidisciplinary
Oxygen
Patients
Peripheral Arterial Disease - therapy
Photosynthesis
Science
Science (multidisciplinary)
Vascular diseases
Vein & artery diseases
Wound Healing
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Summary:Peripheral artery disease and the associated ischemic wounds are substantial causes of global morbidity and mortality, affecting over 200 million people worldwide. Although advancements have been made in preventive, pharmacologic, and surgical strategies to treat this disease, ischemic wounds, a consequence of end-stage peripheral artery disease, remain a significant clinical and economic challenge. Synechococcus elongatus is a cyanobacterium that grows photoautotrophically and converts carbon dioxide and water into oxygen. We present a novel topical biologic gel containing S. elongatus that provides oxygen via photosynthesis to augment wound healing by rescuing ischemic tissues caused by peripheral artery disease. By using light rather than blood as a source of energy, our novel topical therapy significantly accelerated wound healing in two rodent ischemic wound models. This novel topical gel can be directly translated to clinical practice by using a localized, portable light source without interfering with patients’ daily activities, demonstrating potential to generate a paradigm shift in treating ischemic wounds from peripheral artery disease. Its novelty, low production cost, and ease of clinical translatability can potentially impact the clinical care for millions of patients suffering from peripheral arterial disease.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-14085-1