Gum Acacia Stabilized Ag-TiO2 and Ag-SiO2: Sustainable Nanocatalysts for Direct and Convenient Synthesis of 5-Substituted 1H-tetrazoles

We describe the use of biocompatible gum acacia (GA)-assembled Ag-TiO2 and Ag-SiO2 nanostructures as effective heterogeneous catalysts for the synthesis of 5-substituted 1H-tetrazoles through the traditional [3+2] cycloaddition of aryl nitriles with sodium azides. Characterization of the prepared ca...

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Bibliographic Details
Published in:SynOpen (2017) 2023-11, Vol.7 (4), p.680-689
Main Authors: Prakash, Supriya, Sreedhar, Bojja, Naidu, N. V. S.
Format: Article
Language:English
Subjects:
5-substituted 1H-tetrazoles
biocomposites
gum acacia
nanohybrids
silver nanoparticles
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Summary:We describe the use of biocompatible gum acacia (GA)-assembled Ag-TiO2 and Ag-SiO2 nanostructures as effective heterogeneous catalysts for the synthesis of 5-substituted 1H-tetrazoles through the traditional [3+2] cycloaddition of aryl nitriles with sodium azides. Characterization of the prepared catalysts employing TEM, XPS, FE-SEM, FT-IR, XRD, and TGA-DTG reveals silver nanoparticles encapsulated in the GA matrix amidst modified nano titania or silica. A variety of structurally divergent aryl nitriles were converted into the corresponding tetrazoles in a short reaction time. Other advantages include low catalytic load, easy handling of catalyst, limited use of toxic reagents, and desirable conversion yields, making this protocol a viable and practical alternative for this cyclization. The catalysts can be easily recovered and reused over multiple cycles without significant loss of catalytic activity.
ISSN:2509-9396
2509-9396
DOI:10.1055/s-0042-1751511