Hypolipidaemic Effects of Gymnema sylvestre on High Fat Diet Induced Dyslipidaemia in Wistar Rats

Hyperlipidaemia is a well known risk factor for cardiovascular diseases. Lifestyle modification can be the initial step to reduce cholesterol levels. There are various drugs which are used to control dyslipidaemia. Treatment of lipid abnormalities is a lifelong battle. Moreover, the safety and effec...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2017-05, Vol.11 (5), p.FF01-FF05
Main Authors: Singh, Dheeraj Kumar, Kumar, Narendra, Sachan, Anjula, Lakhani, Preet, Tutu, Sachin, Nath, Rajendra, Sachan, Amod Kumar, Dixit, Rakesh Kumar
Format: Article
Language:English
Subjects:
cholesterol
extract
lipid profile
Pharmacology Section
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Summary:Hyperlipidaemia is a well known risk factor for cardiovascular diseases. Lifestyle modification can be the initial step to reduce cholesterol levels. There are various drugs which are used to control dyslipidaemia. Treatment of lipid abnormalities is a lifelong battle. Moreover, the safety and effectiveness of long term lipid lowering treatment are questionable. (GS) is a well known herb with various medicinal properties. To explore the hypolipidaemic activity of leaves extract. Adult healthy female wistar rats, 30 in number, divided into five groups, weighing 150- 200 g were used. Dyslipidaemia was induced in rats by feeding them on high fat diet for four weeks. For the next four weeks GS extract was used as test drug while Atorvastatin was used as standard drug. Blood sample was collected for estimation of lipid profile on day 0, week 4 and week 8. Data was recorded as mean±SEM (Standard error of mean). Paired t-test and one way Analysis of Variance (ANOVA) followed by Dunnett's post hoc test was used for comparison. A p-value
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2017/27430.9859