Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases

Cardiovascular diseases (CVDs) are a group of diseases in which the common denominator is the affection of blood vessels, heart tissue, and heart rhythm. The genesis of CVD is complex and multifactorial; therefore, approaches are often based on multidisciplinary management and more than one drug is...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-08, Vol.23 (16), p.9082
Main Authors: Sánchez-Gloria, José L., Arellano-Buendía, Abraham S., Juárez-Rojas, Juan G., García-Arroyo, Fernando E., Argüello-García, Raúl, Sánchez-Muñoz, Fausto, Sánchez-Lozada, Laura G., Osorio-Alonso, Horacio
Format: Article
Language:English
Subjects:
allicin
Amino acids
Antihypertensives
Blood vessels
Carbohydrates
cardiovascular disease
Cardiovascular diseases
Diabetes
Dietary minerals
Drug therapy
Dyslipidemia
Enzymes
Garlic
Heart
Hypertension
Hypertrophy
Lifestyles
Metabolic disorders
Metabolic syndrome
Mortality
Obesity
Optimal control
Oxidative stress
Pathogenesis
Proteins
Review
Risk analysis
Risk factors
Risk management
Sulfur
Sulfur compounds
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Summary:Cardiovascular diseases (CVDs) are a group of diseases in which the common denominator is the affection of blood vessels, heart tissue, and heart rhythm. The genesis of CVD is complex and multifactorial; therefore, approaches are often based on multidisciplinary management and more than one drug is used to achieve the optimal control of risk factors (dyslipidemia, hypertension, hypertrophy, oxidative stress, endothelial dysfunction, inflammation). In this context, allicin, a sulfur compound naturally derived from garlic, has shown beneficial effects on several cardiovascular risk factors through the modulation of cellular mechanisms and signaling pathways. Effective pharmacological treatments for CVD or its risk factors have not been developed or are unknown in clinical practice. Thus, this work aimed to review the cellular mechanisms through which allicin exerts its therapeutic effects and to show why it could be a therapeutic option for the prevention or treatment of CVD and its risk factors.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23169082