Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment

In order to investigate roles of dopamine receptor subtypes in reward-based learning, we examined choice behavior of dopamine D1 and D2 receptor-knockout (D1R-KO and D2R-KO, respectively) mice in an instrumental learning task with progressively increasing reversal frequency and a dynamic two-armed b...

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Bibliographic Details
Published in:Frontiers in behavioral neuroscience 2014-10, Vol.8, p.368-368
Main Authors: Kwak, Shinae, Huh, Namjung, Seo, Ji-Seon, Lee, Jung-Eun, Han, Pyung-Lim, Jung, Min W
Format: Article
Language:English
Subjects:
Behavior
Choice learning
D1 receptor
D2 receptor
Decision making
Dopamine
Dopamine D1 receptors
Dopamine D2 receptors
dynamic foraging task
Mouse
Neurons
Neuroscience
Reinforcement
reinforcement learning
reversal
Roles
Science
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Summary:In order to investigate roles of dopamine receptor subtypes in reward-based learning, we examined choice behavior of dopamine D1 and D2 receptor-knockout (D1R-KO and D2R-KO, respectively) mice in an instrumental learning task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Performance of D2R-KO mice was progressively impaired in the former as the frequency of reversal increased and profoundly impaired in the latter even with prolonged training, whereas D1R-KO mice showed relatively minor performance deficits. Choice behavior in the dynamic two-armed bandit task was well explained by a hybrid model including win-stay-lose-switch and reinforcement learning terms. A model-based analysis revealed increased win-stay, but impaired value updating and decreased value-dependent action selection in D2R-KO mice, which were detrimental to maximizing rewards in the dynamic two-armed bandit task. These results suggest an important role of dopamine D2 receptors in learning from past choice outcomes for rapid adjustment of choice behavior in a dynamic and uncertain environment.
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2014.00368