The Emergence of the Dose-Response Concept in Biology and Medicine

A historical assessment of the origin of the dose-response in modern toxicology and its integration as a central concept in biology and medicine is presented. This article provides an overview of how the threshold, linear and biphasic (i.e., hormetic) dose-response models emerged in the late 19th an...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2016-12, Vol.17 (12), p.2034-2034
Main Author: Calabrese, Edward J
Format: Article
Language:English
Subjects:
adaptive response
Biology
Biology - methods
biphasic
dose–response
History
History of Medicine
history of science
hormesis
Hormesis - physiology
linear non-threshold
Medicine
Medicine - methods
Models, Biological
Review
Science
threshold
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c577t-37d4ada6c4e98e0254ceb3d04cacadd2c9f00118f066618f53a23c68a92a9c663
cites cdi_FETCH-LOGICAL-c577t-37d4ada6c4e98e0254ceb3d04cacadd2c9f00118f066618f53a23c68a92a9c663
container_end_page 2034
container_issue 12
container_start_page 2034
container_title International journal of molecular sciences
container_volume 17
creator Calabrese, Edward J
description A historical assessment of the origin of the dose-response in modern toxicology and its integration as a central concept in biology and medicine is presented. This article provides an overview of how the threshold, linear and biphasic (i.e., hormetic) dose-response models emerged in the late 19th and early 20th centuries and competed for acceptance and dominance. Particular attention is directed to the hormetic model for which a general description and evaluation is provided, including its historical basis, and how it was marginalized by the medical and pharmacology communities in the early decades of the 20th century.
doi_str_mv 10.3390/ijms17122034
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_6328d4aec9824fa79e9bfcd2376ad489</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_6328d4aec9824fa79e9bfcd2376ad489</doaj_id><sourcerecordid>4301370461</sourcerecordid><originalsourceid>FETCH-LOGICAL-c577t-37d4ada6c4e98e0254ceb3d04cacadd2c9f00118f066618f53a23c68a92a9c663</originalsourceid><addsrcrecordid>eNqNkk1rVDEUhoNYbK3uXMsFNy68bb4_NkI7Vi1UBKnrkEnOnWa4NxmTO0L_vbFTy9RVVyec8_DkJLwIvSH4hDGDT-N6qkQRSjHjz9AR4ZT2GEv1fO98iF7WusaYMirMC3RIlaGGGXqEzq9voLuYoKwgeejy0M2t8SlX6H9A3eRUoVvkNtrMXUzdecxjXt12LoXuG4ToY4JX6GBwY4XX9_UY_fx8cb342l99_3K5OLvqvVBq7pkK3AUnPQejAVPBPSxZwNw770Kg3gwYE6IHLKVsRTBHmZfaGeqMl5Ido8udN2S3tpsSJ1dubXbR3jVyWVlX5uhHsJJR3W4DbzTlg1MGzHLwgTIlXeDaNNfHnWuzXU4QPKS5uPGR9PEkxRu7yr-tIFppxpvg_b2g5F9bqLOdYvUwji5B3lZLtNSMKqbFE1CutKbizvruP3SdtyW1X22UaEKhlWrUhx3lS661wPCwN8H2bybsfiYa_nb_rQ_wvxCwP5I8sO8</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1858325877</pqid></control><display><type>article</type><title>The Emergence of the Dose-Response Concept in Biology and Medicine</title><source>Publicly Available Content Database</source><source>PubMed Central(OpenAccess)</source><creator>Calabrese, Edward J</creator><creatorcontrib>Calabrese, Edward J</creatorcontrib><description>A historical assessment of the origin of the dose-response in modern toxicology and its integration as a central concept in biology and medicine is presented. This article provides an overview of how the threshold, linear and biphasic (i.e., hormetic) dose-response models emerged in the late 19th and early 20th centuries and competed for acceptance and dominance. Particular attention is directed to the hormetic model for which a general description and evaluation is provided, including its historical basis, and how it was marginalized by the medical and pharmacology communities in the early decades of the 20th century.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms17122034</identifier><identifier>PMID: 27929392</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>adaptive response ; Biology ; Biology - methods ; biphasic ; dose–response ; History ; History of Medicine ; history of science ; hormesis ; Hormesis - physiology ; linear non-threshold ; Medicine ; Medicine - methods ; Models, Biological ; Review ; Science ; threshold ; Toxicology</subject><ispartof>International journal of molecular sciences, 2016-12, Vol.17 (12), p.2034-2034</ispartof><rights>Copyright MDPI AG 2016</rights><rights>2016 by the author; licensee MDPI, Basel, Switzerland. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-37d4ada6c4e98e0254ceb3d04cacadd2c9f00118f066618f53a23c68a92a9c663</citedby><cites>FETCH-LOGICAL-c577t-37d4ada6c4e98e0254ceb3d04cacadd2c9f00118f066618f53a23c68a92a9c663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1858325877/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1858325877?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27929392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calabrese, Edward J</creatorcontrib><title>The Emergence of the Dose-Response Concept in Biology and Medicine</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>A historical assessment of the origin of the dose-response in modern toxicology and its integration as a central concept in biology and medicine is presented. This article provides an overview of how the threshold, linear and biphasic (i.e., hormetic) dose-response models emerged in the late 19th and early 20th centuries and competed for acceptance and dominance. Particular attention is directed to the hormetic model for which a general description and evaluation is provided, including its historical basis, and how it was marginalized by the medical and pharmacology communities in the early decades of the 20th century.</description><subject>adaptive response</subject><subject>Biology</subject><subject>Biology - methods</subject><subject>biphasic</subject><subject>dose–response</subject><subject>History</subject><subject>History of Medicine</subject><subject>history of science</subject><subject>hormesis</subject><subject>Hormesis - physiology</subject><subject>linear non-threshold</subject><subject>Medicine</subject><subject>Medicine - methods</subject><subject>Models, Biological</subject><subject>Review</subject><subject>Science</subject><subject>threshold</subject><subject>Toxicology</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1rVDEUhoNYbK3uXMsFNy68bb4_NkI7Vi1UBKnrkEnOnWa4NxmTO0L_vbFTy9RVVyec8_DkJLwIvSH4hDGDT-N6qkQRSjHjz9AR4ZT2GEv1fO98iF7WusaYMirMC3RIlaGGGXqEzq9voLuYoKwgeejy0M2t8SlX6H9A3eRUoVvkNtrMXUzdecxjXt12LoXuG4ToY4JX6GBwY4XX9_UY_fx8cb342l99_3K5OLvqvVBq7pkK3AUnPQejAVPBPSxZwNw770Kg3gwYE6IHLKVsRTBHmZfaGeqMl5Ido8udN2S3tpsSJ1dubXbR3jVyWVlX5uhHsJJR3W4DbzTlg1MGzHLwgTIlXeDaNNfHnWuzXU4QPKS5uPGR9PEkxRu7yr-tIFppxpvg_b2g5F9bqLOdYvUwji5B3lZLtNSMKqbFE1CutKbizvruP3SdtyW1X22UaEKhlWrUhx3lS661wPCwN8H2bybsfiYa_nb_rQ_wvxCwP5I8sO8</recordid><startdate>20161205</startdate><enddate>20161205</enddate><creator>Calabrese, Edward J</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20161205</creationdate><title>The Emergence of the Dose-Response Concept in Biology and Medicine</title><author>Calabrese, Edward J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-37d4ada6c4e98e0254ceb3d04cacadd2c9f00118f066618f53a23c68a92a9c663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>adaptive response</topic><topic>Biology</topic><topic>Biology - methods</topic><topic>biphasic</topic><topic>dose–response</topic><topic>History</topic><topic>History of Medicine</topic><topic>history of science</topic><topic>hormesis</topic><topic>Hormesis - physiology</topic><topic>linear non-threshold</topic><topic>Medicine</topic><topic>Medicine - methods</topic><topic>Models, Biological</topic><topic>Review</topic><topic>Science</topic><topic>threshold</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calabrese, Edward J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals(OpenAccess)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calabrese, Edward J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Emergence of the Dose-Response Concept in Biology and Medicine</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2016-12-05</date><risdate>2016</risdate><volume>17</volume><issue>12</issue><spage>2034</spage><epage>2034</epage><pages>2034-2034</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>A historical assessment of the origin of the dose-response in modern toxicology and its integration as a central concept in biology and medicine is presented. This article provides an overview of how the threshold, linear and biphasic (i.e., hormetic) dose-response models emerged in the late 19th and early 20th centuries and competed for acceptance and dominance. Particular attention is directed to the hormetic model for which a general description and evaluation is provided, including its historical basis, and how it was marginalized by the medical and pharmacology communities in the early decades of the 20th century.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>27929392</pmid><doi>10.3390/ijms17122034</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1422-0067
ispartof International journal of molecular sciences, 2016-12, Vol.17 (12), p.2034-2034
issn 1422-0067
1661-6596
1422-0067
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_6328d4aec9824fa79e9bfcd2376ad489
source Publicly Available Content Database; PubMed Central(OpenAccess)
subjects adaptive response
Biology
Biology - methods
biphasic
dose–response
History
History of Medicine
history of science
hormesis
Hormesis - physiology
linear non-threshold
Medicine
Medicine - methods
Models, Biological
Review
Science
threshold
Toxicology
title The Emergence of the Dose-Response Concept in Biology and Medicine
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T20%3A19%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Emergence%20of%20the%20Dose-Response%20Concept%20in%20Biology%20and%20Medicine&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Calabrese,%20Edward%20J&rft.date=2016-12-05&rft.volume=17&rft.issue=12&rft.spage=2034&rft.epage=2034&rft.pages=2034-2034&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms17122034&rft_dat=%3Cproquest_doaj_%3E4301370461%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c577t-37d4ada6c4e98e0254ceb3d04cacadd2c9f00118f066618f53a23c68a92a9c663%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1858325877&rft_id=info:pmid/27929392&rfr_iscdi=true