Multidrug-Resistant Proteus mirabilis Infections and Clinical Outcome at Tertiary Hospital in Riyadh, Saudi Arabia

( ) is known to cause various infections, most commonly urinary tract infections, and is a threat to hospitalized patients, especially in long-stay departments that utilize invasive devices. This study aims to fill the knowledge gap regarding epidemiology and antimicrobial resistance in Saudi Arabia...

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Bibliographic Details
Published in:Infection and drug resistance 2024-01, Vol.17, p.571-581
Main Authors: Hafiz, Taghreed A, Alghamdi, Ghadi S, Alkudmani, Zeina S, Alyami, Ahmed S, AlMazyed, Abeer, Alhumaidan, Ohoud S, Mubaraki, Murad A, Alotaibi, Fawzia E
Format: Article
Language:English
Subjects:
Ampicillin
Antibacterial agents
Disease susceptibility
Drug resistance in microorganisms
Epidemiology
extensively-drug-resistant
Hospital patients
icu
Lung diseases
mortality
multidrug-resistant
nosocomial infection
Original Research
pan-drug-resistant
Patient outcomes
proteus mirabilis
Risk factors
Urinary tract infections
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Summary:( ) is known to cause various infections, most commonly urinary tract infections, and is a threat to hospitalized patients, especially in long-stay departments that utilize invasive devices. This study aims to fill the knowledge gap regarding epidemiology and antimicrobial resistance in Saudi Arabia. It investigates epidemiological patterns, resistance characteristics, and clinical outcomes among patients at King Fahad Medical City in Riyadh from 2019 to 2021. A total of 598 isolated from diverse clinical specimens, including the clinical information of 78 intensive care unit (ICU) patients, were included in the current study. The Phoenix BD instrument was used for complete identification and sensitivity testing of spp. Demographic, clinical, and outcome data were reported and compared using statistical analysis. Pan-drug-resistant isolates were identified in 2019 (n = 6), although multi- and extensively drug-resistant isolate frequencies were greatest among all patients in 2019. The highest susceptibility levels were observed for piperacillin-tazobactam, carbapenems, and cephalosporins antibiotics. In contrast, Cephalothin, trimethoprim-sulfamethoxazole, and ampicillin had the lowest susceptibilities. Urine infections with a positive culture of were significantly higher in females and non-ICU patients (
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S448335